Long-Term Follow-Up of Surgical Outcomes and Oncological Results of Nipple-Sparing Mastectomy with Immediate Reconstruction Through a Single Axillary Incision with Different Approach Methods.

Background: We investigated the perioperative outcome and oncologic safety of performing nipple-sparing mastectomy (NSM) through a single axillary incision (NSM-SAI) compared with performing NSM through a conventional incision (NSM-C).

Methods: We retrospectively reviewed 725 patients who underwent NSM for breast cancer between January 2010 and December 2023; 333 patients who underwent NSM with immediate reconstruction (IR) were enrolled. Surgical outcomes and oncologic outcomes of NSM-C (n = 184), NSM performed through SAI with a freehand approach (NSM-SAI-F; n = 92), and with an endoscopic approach (NSM-SAI-E; n = 57) were demonstrated.

Leg length discrepancy risk differs between fit-and-fill and taper wedge stems across Dorr types.

Introduction: The comparison between the cementless taper wedge stem and fit-and-fill stem in total hip arthroplasty (THA) for various proximal femoral morphological types has not been thoroughly assessed. This study aimed to compare the risk of leg length discrepancy (LLD) ≥ 10 mm between these two stem types in Dorr type A, B, and C femurs.

Materials And Methods: From April 2015 through April 2021, we analyzed 1178 unilateral primary cementless THA procedures.

A Comparison of Optical Coherence Tomography Angiography Metrics and Artifacts on Scans of Different Sizes in Diabetic Macular Ischemia.

Purpose: Changes in the foveal avascular zone (FAZ) metrics over time are key outcome measures for clinical trials in diabetic macular ischemia (DMI). However, artifacts and automatically delineated FAZ measurements may influence the results. We aimed to compare the artifact frequency and FAZ metrics on 3 × 3 versus 6 × 6 mm optical coherence tomography angiography (OCTA) macular scans in patients with DMI.

The compliance with TTM protocol may benefit outcomes in cardiac arrest survivors: A retrospective cohort study.

Background: Established protocols for implementing high-quality targeted temperature management (TTM) provide guidance concerning the cooling rate, duration of maintenance, and rewarming speed. However, whether compliant to TTM protocols results in improved survival and better neurological recovery has not been examined.

Methods: A retrospective cohort study enrolled 1141 survivors of non-traumatic adult cardiac arrest with a pre-arrest cerebral performance category (CPC) score of 1-2 from 2015 to 2020 at a tertiary medical center.

The cementless taper wedge vs. fit-and-fill stem in primary total hip arthroplasty: risk of stem-related complication differs across Dorr types.

Introduction: The choice between a cementless taper wedge stem and a fit-and-fill stem in total Hip arthroplasty (THA) for various proximal femoral morphological types has not been thoroughly evaluated. This study aimed to compare the risk of stem-related complications between these two stem types in Dorr type A, B, and C femurs.

Materials And Methods: From January 2015 through April 2021, we retrospectively reviewed 1995 cementless THA procedures.

Two Synthetic Tools to Deepen the Understanding of the Influence of Stereochemistry on the Properties of Iridium(III) Heteroleptic Emitters.

Two complementary procedures are presented to prepare -pyridyl-iridium(III) emitters of the class [++] with two orthometalated ligands of the 2-phenylpyridine type () and a third ligand (). They allowed to obtain four emitters of this class and to compare their properties with those of the -pyridyl isomers. The finding starts from IrH(PPr), which reacts with 2-(-tolyl)pyridine to give -[Ir{κ--[CMeH-py]}] with an almost quantitative yield.

Cetuximab for Immunotherapy-Refractory/Ineligible Cutaneous Squamous Cell Carcinoma.

Anti-PD1 therapy demonstrated impressive, prolonged responses in advanced cutaneous squamous cell carcinoma (CSCC). Therapy for ICI-refractory/ineligible disease remains unclear. We performed a retrospective analysis in locally-advanced/metastatic CSCC using cetuximab across three cohorts: immediately after ICI failure (A), not immediately following ICI failure (B), or without prior ICI (C).

Identification of CD8 + T-Cell-Immune Cell Communications in Ileal Crohn's Disease.

Introduction: Crohn's disease (CD) is a major subtype of inflammatory bowel disease (IBD), a spectrum of chronic intestinal disorders caused by dysregulated immune responses to gut microbiota. Although transcriptional and functional changes in a number of immune cell types have been implicated in the pathogenesis of IBD, the cellular interactions and signals that drive these changes have been less well-studied.

Methods: We performed Cellular Indexing of Transcriptomes and Epitopes by sequencing on peripheral blood, colon, and ileal immune cells derived from healthy subjects and patients with CD.

Trial of Endovascular Thrombectomy for Large Ischemic Strokes.

Background: Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations.

Methods: We performed a prospective, randomized, open-label, adaptive, international trial involving patients with stroke due to occlusion of the internal carotid artery or the first segment of the middle cerebral artery to assess endovascular thrombectomy within 24 hours after onset. Patients had a large ischemic-core volume, defined as an Alberta Stroke Program Early Computed Tomography Score of 3 to 5 (range, 0 to 10, with lower scores indicating larger infarction) or a core volume of at least 50 ml on computed tomography perfusion or diffusion-weighted magnetic resonance imaging.

Acetylides for the Preparation of Phosphorescent Iridium(III) Complexes: Iridaoxazoles and Their Transformation into Hydroxycarbenes and -Tetradentate Ligands.

The preparation of three families of phosphorescent iridium(III) emitters, including iridaoxazole derivatives, hydroxycarbene compounds, and -tetradentate containing complexes, has been performed starting from dimers -[Ir(μ-η-C≡CR){κ--(MeCH-py)}] (R = Bu (), Ph ()). Reactions of with benzamide, acetamide, phenylacetamide, and trifluoroacetamide lead to the iridaoxazole derivatives Ir{κ--[C(CHBu)NC()O]}{κ--(MeCH-py)} (R = Ph (), Me (), CHPh (), CF ()) with a disposition of carbons and heteroatoms around the metal center. In 2-methyltetrahydrofuran and dichloromethane, water promotes the C-N rupture of the IrC-N bond of the iridaoxazole ring of to form amidate-iridium(III)-hydroxycarbene derivatives Ir{κ-[NHC()O]}{κ--(MeCH-py)}{═C(CHBu)OH} (R = Me (), CHPh (), CF ()).

Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry.

Background And Objectives: COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.

Methods: This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection.

CD8 T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy.

While food allergy oral immunotherapy (OIT) can provide safe and effective desensitization (DS), the immune mechanisms underlying development of sustained unresponsiveness (SU) following a period of avoidance are largely unknown. Here, we compare high dimensional phenotypes of innate and adaptive immune cell subsets of participants in a previously reported, phase 2 randomized, controlled, peanut OIT trial who achieved SU vs. DS (no vs.

Alkynyl Ligands as Building Blocks for the Preparation of Phosphorescent Iridium(III) Emitters: Alternative Synthetic Precursors and Procedures.

Alkynyl ligands stabilize dimers [Ir(μ-X)(3b)] with a cis disposition of the heterocycles of the 3b ligands, in contrast to chloride. Thus, the complexes of this class─[Ir(μ-η-C≡CPh){κ-,-(CH-Isoqui)}] (Isoqui = isoquinoline) and [Ir(μ-η-C≡CR){κ-,-(MeCH-py)}] (R = Ph, Bu)─have been prepared in high yields, starting from the dihydroxo-bridged dimers [Ir(μ-OH){κ-,-(CH-Isoqui)}] and [Ir(μ-OH){κ-,-(MeCH-py)}] and terminal alkynes. Subsequently, the acetylide ligands have been employed as building blocks to prepare the orange and green iridium(III) phosphorescent emitters, Ir{κ-,-[C(CHPh)Npy]}{κ-,-(CH-Isoqui)} and Ir{κ-,-[C(CHR)Npy]}{κ-,-(MeCH-py)} (R = Ph, Bu), respectively, with an octahedral structure of carbon and nitrogen atoms.

Liver and Spleen Stiffness Surveillance Through Elastography During and After Direct-Acting Antiviral Therapy in Patients With Chronic Hepatitis C.

Objectives: Direct-acting antiviral agents achieve a high cure rate, resulting in early hepatic necroinflammatory resolution and sustained fibrosis regression. This study aimed to obtain longitudinal, concurrent within-subject measurements of liver stiffness (LS) and spleen stiffness (SS) and their correlates over time.

Methods: Participants with hepatitis C (n = 592) receiving direct-acting antiviral-based therapy were monitored through point shear-wave elastography from the treatment baseline (TW0) across follow-up visits in terms of LS and SS.

-Tris(heteroleptic) Red Phosphorescent Iridium(III) Complexes Bearing a Dianionic ,,','-Tetradentate Ligand.

1-Phenyl-3-(1-phenyl-1-(pyridin-2-yl)ethyl)isoquinoline (HMeL) has been prepared by Pd(-XantPhos)-catalyzed "" to synthesize new phosphorescent red iridium(III) emitters (601-732 nm), including the carbonyl derivative Ir(κ--,'--,'-MeL)Cl(CO) and the acetylacetonate compound Ir(κ--,'--,'-MeL)(acac). The tetradentate 6e-donor ligand (6tt') of these complexes is formed by two different bidentate units, namely, an orthometalated 2-phenylisoquinoline and an orthometalated 2-benzylpyridine. The link between the bidentate units reduces the number of possible stereoisomers of the structures [6tt' + 3b] (3b = bidentate 3e-donor ligand), with respect to a [3b + 3b' + 3b″] emitter containing three free bidentate units, and it permits a noticeable stereocontrol.

Effects of Exercise Alone or in Combination with High-Protein Diet on Muscle Function, Aerobic Capacity, and Physical Function in Middle-Aged Obese Adults: A Randomized Controlled Trial.

Background: Obesity accelerates and exacerbates the age-related changes on muscle function and exercise capacity. In addition, the middle-aged population is often overlooked when talking about the prevention of sarcopenia. This study investigated the effects of exercise alone or in combination with a high-protein diet on muscle function and physical fitness in middle-aged obese adults.

Soil CO emission and soil attributes associated with the microbiota of a sugarcane area in southern Brazil.

The spatial structure of soil CO emission (FCO) and soil attributes are affected by different factors in a highly complex way. In this context, this study aimed to characterize the spatial variability patterns of FCO and soil physical, chemical, and microbiological attributes in a sugarcane field area after reform activities. The study was conducted in an Oxisol with the measurement of FCO, soil temperature (Ts), and soil moisture (Ms) in a regular 90 × 90-m grid with 100 sampling points.

Insertion of Unsaturated C-C Bonds into the O-H Bond of an Iridium(III)-Hydroxo Complex: Formation of Phosphorescent Emitters with an Asymmetrical β-Diketonate Ligand.

A synthetic methodology to prepare iridium(III) emitters of the class [3b+3b+3b'] with two -metalated 1-phenylisoquinolines and an asymmetrical β-diketonate has been discovered. The abstraction of the chloride ligands of the dimer [Ir(μ-Cl){κ-,-(CH-isoqui)}] (, CH-isoqui = 1-phenylisoquinoline) with AgBF in acetone and the subsequent addition of water to the resulting solution affords the water solvate mononuclear complex [Ir{κ-,-(CH-isoqui)}(HO)]BF (), which reacts with KOH to give the dihydroxo-bridged dimer [Ir(μ-OH){κ-,-(CH-isoqui)}] (). Treatment of the latter with dimethyl acetylenedicarboxylate leads to Ir{κ-,-(CH-isoqui)}{κ-,-[OC(COCH)CHC(OCH)O]} (), as a result of the -addition of the O-H bond of a mononuclear [Ir(OH){κ-,-(CH-isoqui)}] fragment to the C-C triple bond of the alkyne and the coordination of one of the carboxylate substituents to the metal center.

Phosphorescent Iridium(III) Complexes with a Dianionic C,C',N,N'-Tetradentate Ligand.

To prepare new phosphorescent iridium(III) emitters, 2-phenyl-6-(1-phenyl-1-(pyridin-2-yl)ethyl)pyridine (HL) has been designed and its reactions with [Ir(μ-Cl)(η-COD)] (, COD = 1,5-cyclooctadiene) have been studied. The products obtained depend on the refluxing temperature of the solvent. Thus, complexes Ir(κ-'-L)Cl(CO) (), [Ir(η-COD)(κ-HL)][IrCl(η-COD)] (), and [Ir(μ-Cl)(κL)] () have been formed in 2-ethoxyethanol, propan-2-ol, and 1-phenylethanol, respectively.

Characteristics of Harmonic Indexes of the Arterial Blood Pressure Waveform in Type 2 Diabetes Mellitus.

Type 2 diabetes mellitus (T2DM) is an important public health issue worldwide. T2DM correlates with cardiovascular disease. Arterial stiffness is also a key factor that can be thought of as a surrogate marker.

Scanning atmospheric-pressure plasma jet treatment of nickel oxide with peak temperature of ∼500 °C for fabricating p-i-n structure perovskite solar cells.

Scanning atmospheric-pressure plasma jet (APPJ) treatment of nickel oxide with a peak temperature of 500 °C was performed for fabricating p-i-n structure perovskite solar cells (PSCs). APPJ post-treatment increases the haze of NiO on FTO glass, leading to enhanced light scattering in PSCs that in turn improves the cell efficiency. APPJ treatment on NiO also improves the wettability to facilitate the follow-up deposition of CHNHPbI.

Preparation and Photophysical Properties of (tridentate) Iridium(III) Emitters: Pincer Coordination of 2,6-Di(2-pyridyl)phenyl.

The way to prepare molecular emitters [5t + 4t'] of iridium(III) with a 5t ligand derived from the abstraction of the hydrogen atom at position 2 of the aryl group of 1,3-di(2-pyridyl)benzene (dpybH) is shown. In addition, the photophysical properties of the new emitters are compared with those of their counterparts resulting from the deprotonation of 1,3-di(2-pyridyl)-4,6-dimethylbenzene (dpyMebH), at the same position, which are also synthesized. Treatment of 0.

Predictive Value of NUDT15 Variants on Neutropenia Among Han Chinese Patients with Dermatologic Diseases: A Single-Center Observational Study.

Introduction: Azathioprine is a synthetic purine analogue derived from 6-mercaptopurine which acts by disrupting nucleic acid synthesis and interfering with T cell activation. It is effective in dermatology diseases related to the immune system. However, its side effects, including severe neutropenia, kept patients from using it.