Co-doped MOF-5 and carbon nanotube nanoparticles enhancing stability and high output performance in core-shell nanofibers for piezoelectric nanogenerators.

The interfacial interaction of carbon nanotubes (CNTs) significantly enhances the output capability of piezoelectric nanogenerators (PENGs). However, overcoming the limitation of low specific surface area in one-dimensional materials remains a significant challenge. This paper introduces a hydrothermal method for composite MOF (C-M) using CNTs and MOF-5, demonstrating localized co-doping between them.

Efficient Genome Editing with Chimeric Oligonucleotide-Directed Editing.

Prime editing has emerged as a precise and powerful genome editing tool, offering a favorable gene editing profile compared to other Cas9-based approaches. Here we report new nCas9-DNA polymerase fusion proteins to create chimeric oligonucleotide-directed editing (CODE) systems for search-and-replace genome editing. Through successive rounds of engineering, we developed CODEMax and CODEMax(exo+) editors that achieve efficient genome modifications in human cells with low unintended edits.

An Ultrasensitive Biosensor for Probing Subcellular Distribution and Mitochondrial Transport of l-2-Hydroxyglutarate.

l-2-Hydroxyglutarate (l-2-HG) is a functionally compartmentalized metabolite involved in various physiological processes. However, its subcellular distribution and mitochondrial transport remain unclear owing to technical limitations. In the present study, an ultrasensitive l-2-HG biosensor, sfLHGFR, composed of circularly permuted yellow fluorescent protein and l-2-HG-specific transcriptional regulator, is developed.

First Observation of a Three-Resonance Structure in e^{+}e^{-}→Nonopen Charm Hadrons.

We report the measurement of the inclusive cross sections for e^{+}e^{-}→nOCH (where nOCH denotes non-open charm hadrons) with improved precision at center-of-mass (c.m.) energies from 3.

Antidepressant effects of dexmedetomidine compared with ECT in patients with treatment-resistant depression.

Objective: This pilot study was designed to investigate the antidepressant effects of dexmedetomidine (DEX), a selective α2-adrenergic receptor agonist, in patients with treatment-resistant depression (TRD). The antidepressant effects of dexmedetomidine was compared with ECT, which is widely used in clinical practice for treatment of patients with TRD.

Methods: Seventy six patients with TRD were randomly assigned to receive 10 sessions of DEX infusions or electroconvulsive therapy (ECT) treatment.

NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing.

The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range of the plasma proteome. Here we address these challenges with NUcleic acid Linked Immuno-Sandwich Assay (NULISA™), which improves the sensitivity of traditional proximity ligation assays by ~10,000-fold to attomolar level, by suppressing assay background via a dual capture and release mechanism built into oligonucleotide-conjugated antibodies. Highly multiplexed quantification of both low- and high-abundance proteins spanning a wide dynamic range is achieved by attenuating signals from abundant targets with unconjugated antibodies and next-generation sequencing of barcoded reporter DNA.

White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies.

Background: White matter hyperintensities (WMH) are associated with cognitive dysfunction after ischemic stroke. Yet, uncertainty remains about affected domains, the role of other preexisting brain injury, and infarct types in the relation between WMH burden and poststroke cognition. We aimed to disentangle these factors in a large sample of patients with ischemic stroke from different cohorts.

Electron transport, ferroelectric, piezoelectric and optical properties of two-dimensional InTe: a first-principles study.

Two-dimensional (2D) materials have garnered significant interest in the fields of optoelectronics and electronics due to their unique and diverse properties. In this work, the electron transport, ferroelectric, piezoelectric, and optical properties of 2D InTe were systematically investigated using first-principles based on density functional theory. The analysis of the phonon spectrum and elastic modulus of the Born effective criterion indicates that the structure of the novel 2D InTe is dynamically stable.

Polyfluoroalkyl Chain-Based Assemblies for Biomimetic Catalysis.

Amphiphobic fluoroalkyl chains are exploited for creating robust and diverse self-assembled biomimetic catalysts. Long terminal perfluoroalkyl chains (C F with n=6, 8, and 10) linked with a short perhydroalkyl chains (C H with m=2 and 3) were used to synthesize several 1,4,7-triazacyclononane (TACN) derivatives, C F -C H -TACN. In the presence of an equimolar amount of Zn ions that coordinate the TACN moiety and drive the self-assembly into micelle-like aggregates, the critical aggregation concentration of polyfluorinated C F -C H -TACN⋅Zn was lowered by ∼1 order of magnitude compared to the traditional perhyroalkyl counterpart with identical carbon number of alkyl chain.

Effects of extreme drought events on vegetation activity from the perspectives of meteorological and soil droughts in southwestern China.

Under climate warming, extreme drought events (EDEs) in southwestern China have become more frequent and severe and have had significant impacts on vegetation growth. Clarifying the influence of soil and meteorological droughts on the vegetation photosynthetic rate (PHR) and respiration rate (RER) can help policymakers to anticipate the impacts of drought on vegetation and take measures to reduce losses. In this study, the frequency and features of EDEs from 1990 to 2021 were analyzed using the standardized precipitation evapotranspiration index, and the longest-lasting and most severe EDE was chosen to assess the effects of drought on vegetation activity.

Nuclear Modification Factor of Neutral Pions in the Forward and Backward Regions in p-Pb Collisions.

The nuclear modification factor of neutral pions is measured in proton-lead collisions collected at a center-of-mass energy per nucleon of 8.16 TeV with the LHCb detector. The π^{0} production cross section is measured differentially in transverse momentum (p_{T}) for 1.

Charge Transfer and Level Lifetime in Molecular Photon-Absorption upon the Quantum Impedance Lorentz Oscillator.

On the strength of the new quantum impedance Lorentz oscillator (QILO) model, a charge-transfer method in molecular photon-absorption is proposed and imaged via the numerical simulations of 1- and 2-photon-absorption (1PA and 2PA) behaviors of the organic compounds LB3 and M4 in this paper. According to the frequencies at the peaks and the full width at half-maximums (FWHMs) of the linear absorptive spectra of the two compounds, we first calculate the effective quantum numbers before and after the electronic transitions. Thus, we obtain the molecular average dipole moments, i.

Robust ferroelectricity in low-dimensional -SiX (X = S/Se): a first-principles study.

Low-dimensional ferroelectric materials hold great promise for application in nonvolatile memory devices. In this work, ferroelectricity in two-dimensional monolayers and one-dimensional nanowires based on -SiX (X = S and Se) materials with spontaneous polarization and ferroelectric switching energy barriers has been predicted using the first-principles method. The results show that the intrinsic ferroelectric values due to spontaneous polarization of 2D-SiS, 2D-SiSe, 1D-SiS and 1D-SiSe are 3.

Synthesis and nonlinear optical properties of polyurethane composites containing a pyrene derivative.

The pyrene derivative (PD) was synthesized with pyrene-1-carboxaldehyde and p-aminoazobenzene by a Schiff base reaction. Then the obtained PD was dispersed in polyurethane (PU) prepolymer to prepare polyurethane/pyrene derivative PU/PD materials with good transmittance. The nonlinear optical (NLO) performances of the PD and PU/PD materials were studied by the Z-scan technique under picosecond and femtosecond laser pulses.

Face-to-face interviews versus Internet surveys: Comparison of two data collection methods in the Rome foundation global epidemiology study: Implications for population-based research.

Background And Aims: The Rome Foundation Global Epidemiology Study (RFGES) assessed the prevalence, burden, and associated factors of Disorders of Gut-Brain Interaction (DGBI) in 33 countries around the world. Achieving worldwide sampling necessitated use of two different surveying methods: In-person household interviews (9 countries) and Internet surveys (26 countries). Two countries, China and Turkey, were surveyed with both methods.

Review on the Safety and Efficacy of Brolucizumab for Neovascular Age-Related Macular Degeneration From Major Studies and Real-World Data.

Frequent antivascular endothelial growth factor injections in neovascular age-related macular degeneration (nAMD) often lead to poor compliance and suboptimal outcomes. A longer-acting agent has been a pressing unmet need until recently. Brolucizumab, an antivascular endothelial growth factor agent, is a single-chain antibody fragment approved by the US Food and Drug Administration (FDA) on October 8, 2019, for treating nAMD.

Dynamics of particulate black carbon in the South China Sea: Magnitude, resident timescale, sinking speed, and flux.

The dynamics of particulate black carbon (PBC) in marine environments are poorly understood. Here, radioactive Th was used to constrain the resident timescale, settling speed, and sinking flux of PBC (soot) in the coastal Northeastern South China Sea (NSCS). The PBC concentration varied from 0.

Effects of Epitranscriptomic RNA Modifications on the Catalytic Activity of the SARS-CoV-2 Replication Complex.

SARS-CoV-2 causes individualized symptoms. Many reasons have been given. We propose that an individual's epitranscriptomic system could be responsible as well.

Simultaneous Determination of Methylated Nucleosides by HILIC-MS/MS Revealed Their Alterations in Urine from Breast Cancer Patients.

RNA methylation plays a vital role in the pathogenesis of a variety of diseases including cancer, and aberrant levels of modified nucleosides in RNA were revealed to be related to cancer. Urine is a favored source for biomarker discovery due to the non-invasion to patients. Herein, we developed a sensitive hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC-MS/MS) method combined with stable isotope dilution for accurate quantification of methylated nucleosides in human urine.

Poor bone mineral density aggravates adjacent segment's motility compensation in patients with oblique lumbar interbody fusion with and without pedicle screw fixation: An study.

Objective: Motility compensation increases the risk of adjacent segment diseases (ASDs). Previous studies have demonstrated that patients with ASD have a poor bone mineral density (BMD), and changes in BMD affect the biomechanical environment of bones and tissues, possibly leading to an increase in ASD incidence. However, whether poor BMD increases the risk of ASD by aggravating the motility compensation of the adjacent segment remains unclear.