Designing efficient electrode materials is necessary for supercapacitors but remains highly challenging. Herein, cobalt sulfide with crystalline/amorphous heterophase (denoted as Co(Al)S) derived from an Al metal-organic framework was constructed by ion exchange/acid etching and subsequent sulfidation strategy. It was found that rational sulfidation by adjusting the sulfur source concentration to a suitable level was favorable to form a 3D nanosheet-interconnected network architecture with a large specific surface area, which promoted ion/electron transport and charge separation.
View Article and Find Full Text PDFTransition metal sulfides (TMSs) are promising electrode materials due to their high theoretical specific capacitance, but sluggish charge transfer kinetics and an insufficient number of active sites hamper their applications in supercapacitors. In this work, a self-sacrificial template strategy was employed to construct Al-based MOF-derived metal sulfides with an amorphous/crystalline (a/c) heterophase, in which aluminum, nitrogen, and carbon species were evenly coordinated in the amorphous phase. The metal sulfides a/c-Co(Al)S-1 and a/c-Co(Al)S-2, originating from the CAU-1 and CoAl-MOF on NF as self-sacrificial templates, were investigated as electrode materials, respectively, in which the a/c-Co(Al)S-1 showed a more excellent electrochemical performance.
View Article and Find Full Text PDFRecently a dark matter-electron (DM-electron) paradigm has drawn much attention. Models beyond the standard halo model describing DM accelerated by high energy celestial bodies are under intense examination as well. In this Letter, a velocity components analysis (VCA) method dedicated to swift analysis of accelerated DM-electron interactions via semiconductor detectors is proposed and the first HPGe detector-based accelerated DM-electron analysis is realized.
View Article and Find Full Text PDFThe sustainable production of catechol derivatives is a challenging task. Catechyl (C) and guaiacyl (G) lignins coexisting in waste tung nutshells are promising feedstocks to form valuable catechol derivatives, but the depolymerization of C/G lignin typically involves a catalytic reductive process that cannot produce these oxidized aromatic chemicals. Herein, we demonstrated that the sustainable production of catechol derivative aldehydes and acids from C/G lignin could be achieved through a heterogeneous copper-catalyzed oxidative process.
View Article and Find Full Text PDFInterleukin-27 (IL-27) is known to play opposing roles in immunology. The present paper considers, specifically, the role IL-27 plays in cancer immunotherapy when combined with immune checkpoint inhibitor anti-PD-1. We first develop a mathematical model for this combination therapy, by a system of Partial Differential Equations, and show agreement with experimental results in mice injected with melanoma cells.
View Article and Find Full Text PDFBackground: Dysfunctional attitudes, which are characterized by distorted self-cognitions, were considered to be linked to personality traits. It was found that certain personality traits may predict dysfunctional attitudes in patients with major depressive disorder (MDD). Nonetheless, the relationship between personality traits and dysfunctional attitudes remains under-researched.
View Article and Find Full Text PDFEpidermal growth factor receptor () T790M mutations drive resistance in 50% of patients with advanced non-small cell lung cancer (NSCLC) who progress on first/second generation (1G/2G) EGFR tyrosine kinase inhibitors (TKIs) and are sensitive to Osimertinib. Tissue sampling is the gold-standard modality of T790M testing, but it is invasive. We evaluated the efficacy of Osimertinib in patients with EGFR mutant NSCLC and T790M in circulating tumour DNA (ctDNA).
View Article and Find Full Text PDFDiscerning the effect of pharmacological exposures on intestinal bacterial communities in cancer patients is challenging. Here, we deconvoluted the relationship between drug exposures and changes in microbial composition by developing and applying a new computational method, PARADIGM (parameters associated with dynamics of gut microbiota), to a large set of longitudinal fecal microbiome profiles with detailed medication-administration records from patients undergoing allogeneic hematopoietic cell transplantation. We observed that several non-antibiotic drugs, including laxatives, antiemetics, and opioids, are associated with increased Enterococcus relative abundance and decreased alpha diversity.
View Article and Find Full Text PDFHere the Human Pangenome Reference Consortium presents a first draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of genetically diverse individuals. These assemblies cover more than 99% of the expected sequence in each genome and are more than 99% accurate at the structural and base pair levels.
View Article and Find Full Text PDFA search for exotic dark matter (DM) in the sub-GeV mass range has been conducted using 205 kg day data taken from a p-type point contact germanium detector of the CDEX-10 experiment at China's Jinping underground laboratory. New low-mass dark matter searching channels, neutral current fermionic DM absorption (χ+A→ν+A) and DM-nucleus 3→2 scattering (χ+χ+A→ϕ+A), have been analyzed with an energy threshold of 160 eVee. No significant signal was found; thus new limits on the DM-nucleon interaction cross section are set for both models at the sub-GeV DM mass region.
View Article and Find Full Text PDFTwo-dimensional (2D) heterostructures have attracted a great deal of attention in electrochemical energy storage (EES) due to their unique structure and superior performance. Here, we demonstrate a simple and facile hydrothermal method to prepare 2D porous CeO@CoO sheet-like heterostructures assembled by 3D nanoflake array as basic building units. In the synthesis, a cerium and cobalt acetate mixed solution was obtained the reaction of the mixed solutions of cerium nitrate and cobalt nitrate with sodium hydroxide (NaOH) and acetic acid (HAc), respectively.
View Article and Find Full Text PDFCPT Pharmacometrics Syst Pharmacol
November 2023
The optimal dose for targeted oncology therapeutics is often not the maximum tolerated dose. Pharmacokinetic/pharmacodynamic (PK/PD) modeling can be an effective tool to integrate clinical data to help identify the optimal dose. This case study shows the utility of population PK/PD modeling in selecting the recommended dose for expansion (RDE) for the first-in-patient (FIP) study of PF-06939999, a small-molecule inhibitor of protein arginine methyltransferase 5.
View Article and Find Full Text PDFBiomed Res Int
August 2022
Glioma is the most common intracranial malignancy. is a crucial tumor suppressor gene that plays an essential regulatory role in cell growth, apoptosis, and DNA repair. The rs1042522 C>G polymorphism has been reported to be strongly associated with various tumor risks.
View Article and Find Full Text PDFClassification of the genus Rhacophorus has been problematic. In particular there has been considerable controversy surrounding the phylogenetic relationships among Rhacophorus rhodopus, R. bipunctatus, and R.
View Article and Find Full Text PDFZeolitic imidazole frameworks (ZIFs) have been researched as excellent templates for synthesizing functional materials to be used in various fields. However, direct adoption of ZIFs as electrode material shows dissatisfactory electrochemical performance due to their limited exposed electroactive sites, poor chemical stability and sluggish charging dynamics. Herein, we demonstrate in situ transformation of ZnCo-ZIF frameworks decorated on ZnCo nanorod array (ZnCo-NA) into three-dimensional (3D) spatially distributed ZnCo-LDH/ZnCo-NA heterostructure.
View Article and Find Full Text PDFObjectives: The postoperative outcomes of patients with oral cavity squamous cell carcinoma (OCSCC) vary greatly. To improve risk stratification, we sought to identify genetic biosignatures by whole-exome sequencing (WES).
Materials And Methods: We retrieved patients with OCSCC patients with paired freshly frozen malignant and non-malignant tissue specimens and performed WES by Illumina HiSeq4000 platform.
Adoptive transfer of antigen-specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in some patients. Both the number of transferred T cells and their differentiation state are critical determinants of effective responses. T cells can be expanded with T cell receptor (TCR)-mediated stimulation and interleukin-2, but this can lead to differentiation into effector T cells and lower therapeutic efficacy, whereas maintenance of a more stem-cell-like state before adoptive transfer is beneficial.
View Article and Find Full Text PDFNear-infrared (NIR) can penetrate the dermis. NIR is able to regulate cutaneous component cells and immune cells and shows significant anti-inflammatory therapeutic effects. However, the mechanisms of these effects are largely unknown.
View Article and Find Full Text PDFBackground And Purpose: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic cerebral small vessel disease. The role of intracerebral hemorrhage (ICH) in CADASIL remains elusive. The present study aims to investigate the prevalence, characteristics, and risk factors for ICH in CADASIL.
View Article and Find Full Text PDFBackground: Central nervous system (CNS) tumor is a malignancy commonly seen occurring in childhood, worldwide. Fat mass and obesity-associated (FTO) enzyme, initially identified as an obesity-related protein, also functions as a susceptibility gene for cancers. However, predisposing effect of gene single nucleotide polymorphisms (SNPs) on CNS tumor risk remains unknown.
View Article and Find Full Text PDFIn order to explore the genomic basis for liver cancer metastasis, whole-exome sequencing (WES) was performed on patient-derived hepatocellular carcinoma (HCC) cell lines with differential metastatic potentials and analyzed their clonal evolution relationships. An evolutionary tree based on genomic single nucleotide polymorphism (SNP) was constructed in MegaX software. The WES data showed that the average percentage of heterogeneous mutations in each HCC cell lines was 16.
View Article and Find Full Text PDFBackground: To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk.
Methods: We systematically collated data from randomized, controlled trials. cIMT was assessed as the mean value at the common-carotid-artery; if unavailable, the maximum value at the common-carotid-artery or other cIMT measures were used.
Background and Purpose- Previously, murine models Krit1 Msh2 and Ccm2 Trp53 showed a reduction or no effect on cerebral cavernous malformation (CCM) burden and favorable effects on lesional hemorrhage by the robust Rock (Rho-associated protein kinase) inhibitor fasudil and by simvastatin (a weak pleiotropic inhibitor of Rock). Herein, we concurrently investigated treatment of the more aggressive Pdcd10/Ccm3 model with fasudil, simvastatin, and higher dose atorvastatin to determined effectiveness of Rock inhibition. Methods- The murine models, Pdcd10 Trp53 and Pdcd10 Msh2 , were contemporaneously treated from weaning to 5 months of age with fasudil (100 mg/kg per day in drinking water, n=9), simvastatin (40 mg/kg per day in chow, n=11), atorvastatin (80 mg/kg per day in chow, n=10), or with placebo (n=16).
View Article and Find Full Text PDFDespite major progress in defining the genetic basis of Mendelian disorders, the molecular etiology of many cases remains unknown. Patients with these undiagnosed disorders often have complex presentations and require treatment by multiple health care specialists. Here, we describe an integrated clinical diagnostic and research program using whole-exome and whole-genome sequencing (WES/WGS) for Mendelian disease gene discovery.
View Article and Find Full Text PDFPrevious studies have demonstrated that some single-nucleotide polymorphisms (SNPs) in miRNAs are related to the risk of ischemic stroke (IS), but the conclusions are still controversial and inconclusive. We performed this meta-analysis to further assess the association between miR-146a C>G (rs2910164), miR-149 T>C (rs2292832), miR-196a2 T>C (rs11614913), miR-499 A>G (rs3746444) and risk of IS in Chinese individuals. Relevant studies were identified in the databases of PubMed, Embase.
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