Publications by authors named "C van der Leeuw"
Background: Gene-environment interaction (G × E) is likely an important influence shaping individual differences in alcohol misuse (AM), yet it has not been extensively studied in molecular genetic research. In this study, we use a series of genome-wide gene-environment interaction (GWEIS) and in silico annotation methods with the aim of improving gene identification and biological understanding of AM.
Methods: We carried out GWEIS for four AM phenotypes in the large UK Biobank sample (N = 360,314), with trauma exposure and socioeconomic status (SES) as moderators of the genetic effects.
Article Synopsis
- The corpus callosum (CC) is crucial for communication between the brain's hemispheres, affecting motor responses and executive functions.
- Research investigates genetic factors underlying its structure, linking them to neuropsychiatric disorders and brain development.
- An AI tool was created to analyze CC morphology using large datasets, which revealed genetic overlaps with conditions like ADHD and bipolar disorder, highlighting important biological processes in CC development.
While genome-wide association studies are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging. Here we developed the GSA-MiXeR analytical tool for gene set analysis (GSA), which fits a model for the heritability of individual genes, accounting for linkage disequilibrium across variants and allowing the quantification of partitioned heritability and fold enrichment for small gene sets. We validated the method using extensive simulations and sensitivity analyses.
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- Lytic bacteriophages show potential in treating bacterial infections resistant to antibiotics, but figuring out the best way to use them is still a challenge.
- A study on mice demonstrated that delivering phages directly to the wound (topical application) is much more effective than injecting them into the bloodstream (intravenous).
- The researchers created "HydroPhage," a gel that releases a high concentration of phages over a week, proving to be five times more effective at fighting infections than traditional intravenous methods.
Tropical coastal benthic communities will change in species composition and relative dominance due to global (e.g., increasing water temperature) and local (e.
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