Publications by authors named "C van Hoevell Tot Westerflier"
Article Synopsis
- Cardiovascular disease (CVD) is a major global health issue, making it essential to find biomarkers that can detect it early in healthy people to enhance preventive measures and improve overall health outcomes.
- Various biomarkers, such as atherogenic lipoproteins and inflammatory markers like C-reactive protein (CRP), have shown connections to CVD risk factors, aiding in risk prediction when combined with traditional indicators.
- Emerging biomarkers like myeloperoxidase (MPO) and procalcitonin (PCT) are being explored for their potential in early detection of systemic infections, emphasizing the importance of identifying the best biomarker combinations for effective diagnosis and risk assessment.
The P53 protein, a cancer-associated transcriptional factor and tumor suppressor, houses a Zn ion in its DNA-binding domain (DBD), essential for sequence-specific DNA binding. However, common mutations at position 273, specifically from Arginine to Histidine and Cysteine, lead to a loss of function as a tumor suppressor, also called DNA contact mutations. The mutant (MT) P53 structure cannot stabilize DNA due to inadequate interaction.
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- The study investigates multi-drug resistant Acinetobacter baumannii, focusing on rare clinical isolates from India that produce the pigment pyomelanin.
- Researchers utilized methods like REP-PCR for genotyping and whole genome sequencing to analyze the genomic features of these isolates.
- Findings reveal that pyomelanin-producing strains are not only multidrug-resistant but also form strong biofilms with specific virulence and resistance genes, indicating advanced adaptability and potential health risks.
Article Synopsis
- Acute upper gastrointestinal bleeding (UGIB) has a significant mortality rate of around 10%, and while existing scoring systems exist, none effectively predict mortality outcomes.
- This study conducted in India compared the newly developed ABC score, based on age, blood tests, and comorbidities, against other pre-existing scoring systems to assess its effectiveness in predicting mortality.
- Results showed the ABC score had the highest accuracy (AUROC of 0.75) in predicting 30-day mortality, particularly showing better performance in patients with variceal bleeding compared to non-variceal bleeding.
Article Synopsis
- The study evaluated how palatial root length affects the effectiveness of lidocaine anesthesia in maxillary molar treatments, comparing open-mouth and closed-mouth techniques.
- Sixty patients' pre-operative pain levels were assessed, and they were randomly divided into two groups for the different techniques, with discomfort measured after the anesthesia was administered.
- Results indicated that the closed-mouth technique led to less discomfort and better outcomes than the open-mouth technique, particularly when the palatal root length exceeded 19 mm.