Publications by authors named "C van Herpen"
Introduction: Immune checkpoint inhibition (ICI) is highly effective for the treatment of melanoma, but intrinsic resistance is present in a subgroup of patients. TGF-β pathway activity may play a role in this resistance by preventing T-cells from entering the tumor microenvironment, causing immune escape. We investigated the association of TGF-β signal transduction pathway activity with resistance to ICI treatment in advanced melanoma.
View Article and Find Full Text PDFBackground: As the survival proportions for rare cancers are on average worse than for common cancers, assessing the expected remaining life years in good health becomes highly relevant. This study aimed to estimate the healthy life expectancy (HLE) of a subset of rare and common cancer survivors, and to assess the determinants of poor perceived health in rare cancer survivors.
Methods: To calculate HLE, survival data from the population-based Netherlands Cancer Registry of survivors of a rare cancer (i.
Background: Implementing shared decision-making in oncology practice is often limited, particularly integrating the patient's context into decision-making. To improve this, we conducted a quality improvement project, attempts to accomplish this by: (1) Integrating the patient's context into shared decision-making during consultation with the medical oncologist; (2) Actively involving the GP and case manager (a specialized oncology nurse), who often have knowledge about the patient's context, and; (3) Giving the person with advanced cancer a time-out period of up to 2 weeks to consider and discuss treatment options with others, including close family and friends.
Aim: To explore how persons with advanced cancer and their involved professionals experienced shared decision-making after the introduction of .
Article Synopsis
- Tumors of salivary glands vary widely and can overlap, making them challenging to diagnose, despite advances in molecular testing.
- A study examined 363 cases of 20 different salivary gland tumors and found distinct DNA methylation patterns that help classify these tumors, achieving high accuracy with a machine learning algorithm.
- The research identified specific epigenetic signatures, distinguishing certain tumor types, and suggested that DNA methylation could aid in diagnosing and potentially uncovering new tumor classes in the future.
Article Synopsis
- There is a critical need for new treatments for recurrent salivary gland cancers, with current options being limited.
- A pilot study tested the safety and effectiveness of [Lu]Lu-PSMA-I&T therapy on patients with adenoid cystic carcinoma (AdCC) and salivary duct carcinoma (SDC), aiming to include 10 AdCC and 5 SDC patients.
- Results showed that 67% of AdCC patients were eligible, but there were no objective responses; however, some exhibited stable disease for over 6 months, and the study faced challenges with high screen failure rates in SDC patients.