Publications by authors named "C van Deursen"
Article Synopsis
- Hyperferritinemia affects about 12% of the population, and determining its cause can be challenging, particularly differentiating between normal iron levels and significant iron overload, often assessed through liver MRI.
- Previous guidelines recommend using the liver iron index (LII) from biopsy data, but this study investigates whether LII based on MRI (LII-MRI) of ≥2 can effectively indicate major iron overload by comparing the amount of iron needed for depletion among hyperferritinemia patients.
- Findings indicate that significantly more iron needed to be mobilized in patients with LII-MRI ≥2, and those with lower LII-MRI were more likely to have conditions related to metabolic syndrome, suggesting LII-M
Background: Implantable cardioverter-defibrillators (ICDs) are effective in detecting and treating ventricular arrhythmias. Studies on ICD therapy for different indications (primary and secondary prevention) and possible predictors of ICD therapy are limited. In this study, the incidence and type of ICD therapy were related to the indication and the underlying cardiac pathology.
View Article and Find Full Text PDFAims: Left ventricular (LV) blood flow is determined by intraventricular pressure gradients (IVPG). Changes in blood flow initiate remodelling and precede functional decline. Novel cardiac magnetic resonance (CMR) post-processing LV-IVPG analysis might provide a sensitive marker of LV function in dilated cardiomyopathy (DCM).
View Article and Find Full Text PDFInhibitory neurons originating from the ventral forebrain are associated with several neurological conditions. Distinct ventral forebrain subpopulations are generated from topographically defined zones; lateral-, medial- and caudal ganglionic eminences (LGE, MGE and CGE), yet key specification factors often span across developing zones contributing to difficulty in defining unique LGE, MGE or CGE profiles. Here we use human pluripotent stem cell (hPSC) reporter lines (NKX2.
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