Canagliflozin prevents acute kidney Injury in euglycemics rats.

The aim of this study was to investigate the impact of canagliflozin on AKI caused by ischemia-reperfusion injury (IRI) in non-diabetic rats. Male Wistar rats weighing 250-300g were randomized into four groups: SHAM (rats subjected to sham renal ischemia-reperfusion surgery); CANA (canagliflozin by gavage, 200mg/kg, once, daily, 5 days); I/R: rats subjected to I/R- AKI (bilateral renal hilum clamping, 30 minutes); CANA+I/R: I/R rats that received canagliflozin 5 days prior to I/R. Evaluated parameters: renal function (serum creatinine [CrS], inulin clearance [inCl]; renal hemodynamics (mean arterial pressure [MAP], renal blood flow [RBF], renal vascular resistance [RVR]); redox profile (urinary peroxides, lipid peroxidation, urinary nitrate, renal tissue thiols and nuclear factor erythroid 2-related factor 2 [Nrf2] protein expression), western blot for identification of SGLT2 in the kidneys and renal histology.

Does music training improve emotion recognition and cognitive abilities? Longitudinal and correlational evidence from children.

Music training is widely claimed to enhance nonmusical abilities, yet causal evidence remains inconclusive. Moreover, research tends to focus on cognitive over socioemotional outcomes. In two studies, we investigated whether music training improves emotion recognition in voices and faces among school-aged children.

Leveraging infrared spectroscopy for cocoa content prediction: A dual approach with Kohonen neural network and multivariate modeling.

People of all ages enjoy chocolate, and its popularity is attributed to its pleasant taste and aroma, as well as its associated health benefits. Produced through both artisanal and industrial processes, which involve harvesting, selecting, fermenting, roasting and grinding cocoa beans, chocolate has a diverse chemical composition. It contains stimulants for the central nervous system, including caffeine and theobromine, and antioxidants and flavonoids, some of which are associated with promoting cardiovascular health, circulatory function, alertness, and attention.