Attributes of clinical guidelines that influence use of guidelines in general practice: observational study.

Objective: To determine which attributes of clinical practice guidelines influence the use of guidelines in decision making in clinical practice.

Design: Observational study relating the use of 47 different recommendations from 10 national clinical guidelines to 12 different attributes of clinical guidelines-for example, evidence based, controversial, concrete.

Setting: General practice in the Netherlands.

Nasal hyperreactivity and inflammation in allergic rhinitis.

The history of allergic disease goes back to 1819, when Bostock described his own 'periodical affection of the eyes and chest', which he called 'summer catarrh'. Since they thought it was produced by the effluvium of new hay, this condition was also called hay fever. Later, in 1873, Blackley established that pollen played an important role in the causation of hay fever.