Minimizing Selection Bias in Inclusive Jets in Heavy-Ion Collisions with Energy Correlators.

The first-ever measurement of energy correlators within inclusive jets produced in heavy-ion collisions, revealed by the CMS Collaboration, shows a clear enhancement at large angles relative to the proton-proton (p-p) baseline. However, interpreting this enhancement is complicated due to selection bias from energy loss, which also distorts the energy correlator heavy-ion to p-p ratio in the hadronization region, hindering our understanding of parton/hadron dynamics in a colored medium. In this Letter, we introduce a new ratio of energy correlator observables that removes the leading effects of selection bias from the two-point energy correlator spectrum (E2C).

Early experience on universal prophylaxis in infants against RSV: Facts and expectations.

During the 2023-2024 season, nirsevimab significantly reduced the risk of bronchiolitis and confirmed RSV infections in primary care, hospital, and pediatric intensive care unit admissions among infants aged 0 to 11 months, even in a season with a high community RSV burden, particularly for older infants. These findings are very useful for public health authorities to continue to implement immunization campaigns against RSV in the coming seasons. Moreover, universal immunization against RSV represents a transformative step towards reducing the burden of RSV in infants.

From Psychoactivity to Antimicrobial Agents: Multifaceted Applications of Synthetic Cathinones and Extracts.

The emergence of new psychoactive substances (NPS) in the global drug market since the 2000s has posed major challenges for regulators and law enforcement agencies. Among these, synthetic cathinones have gained prominence due to their stimulant effects on the central nervous system, leading to widespread recreational use. These compounds, often marketed as alternatives to illicit stimulants such as amphetamines and cocaine, have been linked to numerous cases of intoxication, addiction and death.

Bioimaging marine crustacean brain: quantitative comparison of micro-CT preparations in an Alpheid snapping shrimp.

Non-invasive bioimaging techniques like X-ray micro-computed tomography (μCT), combined with contrast-enhancing techniques, allow the 3D visualization of the central nervous system , without the destruction of the sample. However, quantitative comparisons of the most common fixation and contrast-enhancing protocols are rare, especially in marine invertebrates. Using the snapping shrimp () as a model, we test three common fixation and staining agents combinations to prepare specimens prior to μCT scanning.

Dynamic Expression of Genes Encoding Ubiquitin Conjugating Enzymes (E2s) During Neuronal Differentiation and Maturation: Implications for Neurodevelopmental Disorders and Neurodegenerative Diseases.

The ubiquitination process plays a crucial role in neuronal differentiation and function. Numerous studies have focused on the expression and functions of E3 ligases during these different stages, far fewer on E2 conjugating enzymes. In mice, as in humans, these E2s belong to 17 conjugating enzyme families.