Publications by authors named "C d'Enfert"
The cell wall of human fungal pathogens plays critical roles as an architectural scaffold and as a target and modulator of the host immune response. Although the cell wall of the pathogenic yeast is intensively studied, one of the major fibrillar components in its cell wall, β-1,6-glucan, has been largely neglected. Here, we show that β-1,6-glucan is essential for bilayered cell wall organization, cell wall integrity, and filamentous growth.
View Article and Find Full Text PDFCandidaalbicans normally colonizes the human gastrointestinal tract as a commensal. Studying fungal factors involved in colonizing the mammalian gastrointestinal tract requires mouse models with altered microbiota. We have obtained strains of C.
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- Candidalysin is a toxin produced by Candida species, playing a significant role in causing mucosal infections and damaging host tissues, which exacerbates diseases and immune responses.* -
- Recent studies discovered multiple variants of candidalysin in different Candida isolates, indicating a wider genetic diversity and potential differences in how they affect host cells.* -
- Experiments showed that these candidalysin variants cause varying levels of cellular damage and biological responses in epithelial cells, highlighting their importance in understanding fungal infections.*
Candida albicans is a commensal of the human microbiota that can form biofilms on implanted medical devices. These biofilms are tolerant to antifungals and to the host immune system. To identify novel genes modulating C.
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- The human fungal pathogen highlighted in the study was previously thought to lack a functional RNAi pathway, but it was found that its widely used reference strain has a mutation in the essential Argonaute gene.
- Most other isolates of this pathogen possess a functional Argonaute, suggesting a robust RNAi machinery that regulates specific gene families, emphasizing the need for diverse reference strains in research.