Publications by authors named "C Zingaretti"
Article Synopsis
- Long-term survivors of pancreatic cancer after surgery are rare, and a recent Italian survey aims to understand factors affecting their survival outcomes.
- The survey, endorsed by key oncological associations, gathered responses from surgeons to analyze demographics, clinical practices, and survival rates, revealing that long-term survival (LTS) is defined as being alive at 5 years post-surgery.
- Findings indicated improved survival rates for patients post-2013, especially in high-volume centers with multidisciplinary approaches, as well as those receiving neoadjuvant chemotherapy and having low-grade tumors.
Background: Genetic And Morphological Evaluation (GAME) score is the newest prognostic model for patient with colorectal liver metastases (CRLMs). Pathological and radiological responses to neoadjuvant chemotherapy (NAC) are key factors for prognostic stratification of these patients. The present study aims to evaluate the GAME-score's ability to predict pathological and radiologic responses to NAC.
View Article and Find Full Text PDFThe breadth and depth at which cancer models are interrogated contribute to the successful clinical translation of drug discovery efforts. In colorectal cancer (CRC), model availability is limited by a dearth of large-scale collections of patient-derived xenografts (PDXs) and paired tumoroids from metastatic disease, where experimental therapies are typically tested. Here we introduce XENTURION, an open-science resource offering a platform of 128 PDX models from patients with metastatic CRC, along with matched PDX-derived tumoroids.
View Article and Find Full Text PDFIntroduction: The discovery of oncogenic mutations that drive the growth and progression of Non-small-cell lung cancer (NSCLC) led to the development of a range of molecular targeted therapies. Tyrosine kinase inhibitors (TKIs) improve the overall outcome of patients with oncogene addicted NSCLC, ensure a better compliance to treatment and few side effects compared to traditional chemotherapy. However, the treatment is still completely "drug-centric", in a population of patients who usually survive for a long time and desire to regain their quality of life.
View Article and Find Full Text PDFBackground: This study analyzed the Quality of Life (QoL) and cost-effectiveness of laparoscopic (LDP) versus robotic distal pancreatectomy (RDP).
Methods: Consecutive patients submitted to LDP or RDP from 2010 to 2020 in four high-volume Italian centers were included, with a minimum of 12 months of postoperative follow-up were included. QoL was evaluated using the EORTC QLQ-C30 and EQ-5D questionnaires, self-reported by patients.