Publications by authors named "C Zarras"

Article Synopsis
  • - The study focuses on Clostridioides difficile infection (CDI), a major cause of healthcare-related diarrhea, examining its incidence and clinical features in a northern Greece hospital during 2022-2023.
  • - Out of 4,560 patients, 104 were identified with CDI, and the incidence rate was notably higher than previous reports at 54.6 cases per 10,000 patient days, along with a concerning 30-day mortality rate of 39.4%.
  • - The findings highlight the emergence of hypervirulent strains and the prevalence of multidrug-resistant organisms, calling for improved surveillance and infection prevention strategies in healthcare settings.
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Candida auris is an emerging fungal pathogen associated with multi-drug resistance rates and widespread outbreaks in hospitals and healthcare units worldwide. Sequencing studies have revealed that different clonal lineages of the fungus seem to be prevalent among distinct geographical sites. The first case of C.

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Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% of these sepsis deaths could be prevented through improved treatment, the efficacy of the currently recommended first- and second-line treatment regimens for this condition is increasingly affected by high rates of drug resistance. Here we assess three well known antibiotics, fosfomycin, flomoxef and amikacin, in combination as potential antibiotic treatment regimens by investigating the drug resistance and genetic profiles of commonly isolated GNB causing neonatal sepsis in LMICs.

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We report the rare case of bacteraemia and secondary spondylodiscitis probably triggered by tooth injury in a rheumatoid arthritis patient. Anaerobic bacteria associated spondylodiscitis may evade diagnosis due to atypical clinical presentation usually lacking fever, and the difficulties related to microbiological characterisation of the pathogen. Even though anaerobic spinal infections may constitute <3% of the total, clinical suspicion should remain high, especially in the case of positive history for pre-existing oral cavity or gastrointestinal/gynaecological tract infections.

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