On the possible use of hydraulic force to assist with building the step pyramid of saqqara.

The Step Pyramid of Djoser in Saqqara, Egypt, is considered the oldest of the seven monumental pyramids built about 4,500 years ago. From transdisciplinary analysis, it was discovered that a hydraulic lift may have been used to build the pyramid. Based on our mapping of the nearby watersheds, we show that one of the unexplained massive Saqqara structures, the Gisr el-Mudir enclosure, has the features of a check dam with the intent to trap sediment and water.

Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism.

Human African trypanosomiasis (HAT), or sleeping sickness, is a neglected tropical disease with current treatments marred by severe side effects or delivery issues. To identify novel classes of compounds for the treatment of HAT, high throughput screening (HTS) had previously been conducted on bloodstream forms of T. b.

Yttrium speciation variability in bauxite residues of various origins, ages and storage conditions.

Bauxite residues (BRs) are highly alkaline wastes generated during alumina production from bauxite ore. Billions of tons have been accumulating worldwide for more than 100 years, they are stored in various forms, and pose environmental and societal issues. At the same time, BRs are promising secondary sources for the production of critical metals including rare earth elements (REEs).

Uncovering factors influencing railway passenger experiences through love and breakup declarations.

While existing approaches for assessing passenger experience are often limited to surveys of customer satisfaction, societal and technological challenges push the railway industry to adopt a user-centric approach to the design of their service. We used the love and breakup method in a study involving N = 53 passengers making a declaration to their railway company to collect qualitative feedback on the passenger experience. The method allowed to gather personal, emotional, and contextual insights into passengers' experiences that can inform the transportation service design process.

Loss of CD24 promotes radiation‑ and chemo‑resistance by inducing stemness properties associated with a hybrid E/M state in breast cancer cells.

Cancer stem cells (CSCs) serve an essential role in failure of conventional antitumor therapy. In breast cancer, CD24/CD44 phenotype and high aldehyde dehydrogenase activity are associated with CSC subtypes. Furthermore, CD24/CD44 pattern is also characteristic of mesenchymal cells generated by epithelial‑mesenchymal transition (EMT).