Characterization of Factors Associated With Death in Deceased Patients With Mitochondrial Disorders: A Multicenter Cross-Sectional Survey.

Background And Objectives: Mitochondrial disorders are multiorgan disorders resulting in significant morbidity and mortality. We aimed to characterize death-associated factors in an international cohort of deceased individuals with mitochondrial disorders.

Methods: This cross-sectional multicenter observational study used data provided by 26 mitochondrial disease centers from 8 countries from January 2022 to March 2023.

Discovery and Development of CFTR Modulators for the Treatment of Cystic Fibrosis.

Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which regulates ion and fluid transport across epithelial cells. Mutations lead to complications, with life-limiting lung disease being the most severe manifestation. Traditional treatments focused on managing symptoms, but advances in understanding CF's molecular basis led to small-molecule CFTR modulators.

Determining the diagnostic cut-off on the Chinese version of severity of dependence scale for cannabis.

Introduction: Cannabis use and misuse are surging among the Chinese community in East and Southeast Asia. A quick screening instrument that can effectively identify users with dependence for early intervention is in utmost need. This study examined the psychometric properties of the Chinese version of the Severity of Dependence Scale for cannabis (C-SDS-C) in screening for the DSM-5 defined Cannabis Use Disorder (CUD).

Dispersive gains enhance wireless power transfer with asymmetric resonance.

Parity-time (PT) symmetry is a fundamental concept in non-Hermitian physics that has recently gained attention for its potential in engineering advanced electronic systems and achieving robust wireless power transfer (WPT) even in the presence of disturbances, through the incorporation of nonlinearity. However, the current PT-symmetric scheme falls short of achieving the theoretical maximum efficiency of WPT and faces challenges when applied to non-resistive loads. In this study, we propose a theoretical framework and provide experimental evidence demonstrating that asymmetric resonance, based on dispersive gain, can greatly enhance the efficiency of WPT beyond the limits of symmetric approaches.