Publications by authors named "C Y Stroud"
Background: Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared to its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK is required to inform management.
Objectives: To describe the disease burden of AAE-C1-INH, long-term prophylaxis (LTP) and the clinical, immunochemical and treatment profiles of AAE-associated diseases in UK.
Article Synopsis
- Dry deposition plays a significant role in removing reactive organic carbon from the atmosphere, impacting airborne chemical reactions and transferring this carbon to other environmental systems.
- Using aircraft measurements, researchers found that oil operations can lead to high deposition rates of organic carbon, reaching up to 100 tons per hour, with rapid lifetimes of about 4 hours that can compete with oxidation processes.
- Traditional models for gas-phase deposition may not capture all deposited organic carbon, indicating a need to consider these deposition processes in assessing the effects on freshwater ecosystems, as they contribute significantly to the overall carbon balance compared to terrestrial sources.
Background: Bacterial infection of the intervertebral disc is difficult to treat because the tissue is usually not vascularized and systemic antibiotic therapy may not reach optimal antibacterial exposure. Here we characterize the safety, tolerability, and pharmacokinetics of PP353, a suspension of micronized linezolid, formulated for direct intervertebral disc administration.
Methods: The safety, tolerability, and pharmacokinetics of an intradiscal administration of PP353, was assessed in Part A of a Phase 1b study and consisted of a single injection of study drug (3 mL of PP353 and 150 mg linezolid).
Background: X-linked agammaglobulinaemia (XLA), caused by mutations in BTK, is characterised by low or absent peripheral CD19 + B lymphocytes and agammaglobulinaemia. The mainstay of treatment consists of immunoglobulin replacement therapy (IgRT). As this cannot fully compensate for the immune defects in XLA, patients may therefore continue to be at risk of complications.
View Article and Find Full Text PDFThough considerable work supports the Dimensional Model of Adversity and Psychopathology, prior research has not tested whether the dimensions-threat (e.g., abuse) and deprivation (e.
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