Electrochemical Glucose Sensor Based on Dual Redox Mediators.

Electrochemical glucose sensor holds significant promise for the monitoring of blood glucose levels in diabetic patients. In this study, we proposed a novel electrochemical glucose sensor based on 1,10-Phenanthroline-5,6-dione (PD)/Ru(III) as a dual redox mediator. The synergistic effect of PD and Ru(III) was utilized to efficiently facilitate the electron transfer between the enzyme-active center and the electrode.

Quaternary ammonium chitosan-functionalized mesoporous silica nanoparticles: A promising targeted drug delivery system for the treatment of intracellular MRSA infection.

The limited membrane permeability and bacterial resistance pose significant challenges in the management of intracellular drug-resistant bacterial infections. To overcome this issue, we developed a bacterial-targeted drug delivery system based on quaternary ammonium chitosan-modified mesoporous silica nanoparticles (MSN-NH-CFP@HACC) for the treatment of intracellular Methicillin-resistant Staphylococcus aureus (MRSA) infections. This system utilizes amino-functionalized mesoporous silica nanoparticles to efficiently load cefoperazone (CFP), and the nanoparticles' surface is coated with 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) to target bacteria and enhance macrophage uptake.

Diversity of (Symplocaceae, Ericales) at low latitudes in Asia during late Oligocene and Miocene.

•Three types of from the late Oligocene and Miocene of Guangxi showcase the diversity of during this time.•Earliest Asian megafossils of are from the late Oligocene of Nanning Basin, Guangxi, China.•Fossils and modeling reveal was quite diverse and has persisted at low latitudes within Asia since late Oligocene.

Adhesive transparent antimicrobial quaternized chitosan/oxidized dextran/polydopamine nanoparticle hydrogels for accelerated wound healing.

Hydrogels possessing appropriate adhesion and antibacterial properties have emerged as promising dressings for expediting wound healing, while also providing the convenience of visualizing the wound site to accurately monitor the healing process. In this study, we incorporated oxidized and degraded polydopamine nanoparticles into quaternized chitosan/oxidized dextran hydrogel QOP series, resulting in enhanced transmittance exceeding 95 % and adhesion strengths reaching up to 19.4 kPa.

OsNCED5 confers cold stress tolerance through regulating ROS homeostasis in rice.

Cold stress is one of the most serious abiotic stresses that affects the growth and yield in rice. However, the molecular mechanism by which abscisic acid (ABA) regulates plant cold stress tolerance is not yet clear. In this study, we identified a member of the OsNCED (9-cis-epoxycarotenoid dioxygenase) gene family, OsNCED5, which confers cold stress tolerance in rice.