Enrolment characteristics in age-related macular degeneration clinical trials: a cross-sectional study.

Background/objectives: To investigate demographic enrolment characteristics in age-related macular degeneration (AMD) trials.

Subjects/methods: Clinicaltrials.gov was searched with "age-related macular degeneration" to identify RCTs with double, triple, or quadruple masking.

The Preaponeurotic Fat Advancement Pedicle for Correction of Upper Eyelid Volume Asymmetry: A Case Series.

Preoperative volume asymmetry in the upper eyelid sulci can pose a challenge in achieving symmetry after upper eyelid blepharoplasty. Reported methods to improve volume asymmetry include the use of soft tissue filler and various surgical techniques. The authors present 6 cases where a central preaponeurotic fat advancement pedicle was utilized during upper eyelid blepharoplasty for improved upper eyelid symmetry (Fig.

Integrating rare pathogenic variant prioritization with gene-based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease.

Introduction: Increasing evidence has highlighted rare variants in Alzheimer's disease (AD). However, insufficient sample sizes, especially in underrepresented ethnic groups, hinder their investigation. Additionally, their impact on endophenotypes remains largely unexplored.

Aldo-keto reductase family 1 member B10 prevents esophageal squamous cell carcinoma from reactive carbonyl species-induced cell death and promotes its progression.

Introduction: Chronic alcohol consumption and tobacco usage are major risk factors for esophageal squamous cell carcinoma (ESCC). Excessive tobacco and alcohol consumption lead to oxidative stress and the generation of reactive carbonyl species (RCS) which induce DNA damage and cell apoptosis. This phenomenon contributes to cell damage and carcinogenesis in various organs including ESCC.