Publications by authors named "C Y Kwan"
The anti-dyskinetic effect of the clinic-ready mGluRpositive allosteric modulator AZD8529 in the 6-OHDA-lesioned rat.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
L-3,4-dihydroxyphenylalanine (L-DOPA) remains the main treatment for motor symptoms of Parkinson's disease (PD). However, chronic use is associated with the development of complications such as L-DOPA-induced dyskinesia. We previously demonstrated that LY-487,379, a highly selective metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM), reduces the severity of L-DOPA-induced abnormal involuntary movements (AIMs) in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of PD, without interfering with the anti-parkinsonian action of L-DOPA.
View Article and Find Full Text PDFUptake and service preferences of human papillomavirus vaccination in men who have sex with men.
Hum Vaccin Immunother
December 2025
Human papillomavirus (HPV) vaccination could reduce HPV infection in men who have sex with men (MSM), but the published statistics on HPV vaccination uptake in MSM were scarce globally. This study estimated the uptake and profiled the service preferences of HPV vaccination of Chinese MSM in Hong Kong. Adult MSM were recruited through non-governmental organizations (NGOs) and online channels for completing an online baseline survey.
View Article and Find Full Text PDFPurpose: To develop and pilot-test a novel training programme for nurses in acute care settings to improve their decision-making support skills, knowledge, attitudes, and confidence in conducting advance care planning (ACP).
Methods: A single-group repeated measures design was employed. This study was conducted in two phases.
Article Synopsis
- Esophagogastric junction outflow obstruction (EGJOO) is an esophageal disorder with a high integrated relaxation pressure, and while symptoms are usually self-limiting, this study investigates factors that affect symptom resolution.
- A cohort study of 53 patients revealed that while dysphagia and atypical chest pain were common symptoms, obesity was a significant risk factor for persistent symptoms, with only 37.5% of obese patients seeing resolution compared to 87.2% of non-obese patients.
- The study emphasizes that addressing obesity may be crucial for improving outcomes in patients with functional EGJOO, as it significantly impacts the likelihood of symptom resolution.
Benefits of chest wall mobilization on respiratory efficiency and functional exercise capacity in people with severe chronic obstructive pulmonary disease (COPD): A randomized controlled trial.
Respirology
September 2024
Article Synopsis
- The study explored how chest wall mobilization affects exercise capacity and respiratory muscle function in men with severe COPD.
- Participants (30 males, average age 75) were divided into a chest wall mobilization group and a control group, both receiving exercise education, but only the CWMG received additional mobilization treatments.
- Results showed that the CWMG had significantly improved exercise tolerance, reduced muscle activity during tests, and maintained these benefits three months after the program, highlighting the potential advantages of chest wall mobilization in COPD rehabilitation.