Publications by authors named "C Y B Chin"
Introduction: Pharmacogenomic testing in psychiatry is an emerging area with potential clinical application of guiding medication choice and dosing. Interest has been fanned by commercial pharmacogenomic providers who have commonly marketed combinatorial panels that are direct-to-consumer. However, this has not been adopted widely due to a combination of barriers that include a varying evidence base, clinician and patient familiarity and acceptance, uncertainty about cost-effectiveness, and regulatory requirements.
View Article and Find Full Text PDFBlood pressure (BP) measurement is a major physiological information for people with cardiovascular diseases, such as hypertension, heart failure, and atherosclerosis. Moreover, elders and patients with kidney disease and diabetes mellitus also are suggested to measure their BP every day. The cuffless BP measurement has been developed in the past 10 years, which is comfortable to users.
View Article and Find Full Text PDFAim: Physician visual assessment (PVA) in invasive coronary angiography (ICA) is clinically used to determine stenosis severity and guide coronary intervention. However, PVA provides limited information regarding the haemodynamic significance of stenosis. This prospective study aimed to develop a model combining visual diameter stenosis (DS) and quantitative coronary angiography (QCA)-derived parameters to diagnose ischaemic lesions using invasive fractional flow reserve (FFR) with pharmacologically induced maximal hyperaemia as the gold standard.
View Article and Find Full Text PDFArticle Synopsis
- The ataxia-telangiectasia mutated (ATM) gene plays a crucial role in cell checkpoint signaling and repairing DNA damage, particularly double-stranded breaks.
- A 50-year-old woman with stage IIIA breast cancer had genetic testing revealing harmful mutations in the ATM gene, making her less able to handle radiation therapy.
- Despite guidelines suggesting that radiation treatment is safe for individuals with ATM mutations, she suffered severe side effects, including brachial plexopathy, which hadn't been previously linked to these specific mutations.
Article Synopsis
- Intra and inter-pathologist variability complicates the evaluation of metabolic dysfunction-associated steatohepatitis (MASH) biopsy results, hindering patient selection and assessment quality in clinical trials.
- A study analyzed 120 histology slides with and without AI assistance to evaluate its impact on pathologists' reliability in fibrosis staging, especially for early fibrosis stages.
- Results showed that AI assistance significantly improved concordance among pathologists, increasing agreement rates for clinical trial inclusion and exclusion, which could enhance the overall efficiency and reliability of MASH-related clinical research.