Publications by authors named "C Xhaard"
Article Synopsis
- The study aims to identify biomarkers linked to new-onset kidney function decline in initially healthy individuals, ultimately improving patient management.
- It analyzed data from 1,087 participants over a 20-year period, focusing on the relationship between proteins and gene expressions and changes in glomerular filtration rate (GFR).
- Key findings included several proteins and genes associated with kidney dysfunction, highlighting the roles of extracellular matrix, cardiovascular remodeling, and inflammation in early GFR decline and suggesting potential avenues for future research in biomarkers and treatments.
Article Synopsis
- - French Polynesia (FP) has a high incidence of differentiated thyroid cancer (DTC), and this study examined the genetic factors contributing to DTC risk in the native population, particularly due to past nuclear tests from 1966-1974.
- - Researchers analyzed over 300,000 single nucleotide polymorphisms (SNPs) in 283 DTC cases and 418 controls, discovering genetic links associated with DTC at three specific regions on chromosomes 6, 10, and 17, indicating an increased risk.
- - The findings suggest that these genetic loci could influence DTC risk, but the study recommends further investigation using whole genome sequencing to better understand these factors, as the current methods may not fully capture the
Background: The expression of NGAL/lcn2 (neutrophil gelatinase-associated lipocalin) is directly modulated by mineralocorticoid receptor activation but its role in blood pressure control is unclear.
Methods: a potential relationship between NGAL plasma levels, systolic blood pressure and urinary Na excretion was assessed in the STANISLAS cohort. The specific role of NGAL/lcn2 in salt-sensitive hypertension was studied using lcn2-knockout mice (lcn2 KO) fed with low-Na diet (0Na).
Layer myocardial strain is the most heritable echocardiographic trait.
Eur Heart J Cardiovasc Imaging
September 2023
Aims: Myocardial deformation assessed by strain analysis represents a significant advancement in our assessment of cardiac mechanics. However, whether this variable is genetically heritable or whether all/most of its variability is related to environmental factors is currently unknown. We sought to determine the heritability of echocardiographically determined cardiac mechanics indices in a population setting.
View Article and Find Full Text PDFBackground: Pulse wave velocity (PWV) is a marker of arterial stiffness, which is intrinsically highly correlated with blood pressure (BP). However, the interplay of PWV and BP heritability has not been extensively studied. This study aimed to estimate the heritability of PWV and BP and determine the genetic correlation between PWV and BP.
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