Publications by authors named "C Xaus"
Article Synopsis
- The study focused on oxidative stress responses in the livers of aging rats, comparing different age groups (1.5, 3, 18, and 24 months).
- The findings showed fluctuations in key indicators: superoxide levels increased at certain ages, while nitric oxide levels notably declined in older rats, potentially reducing antioxidant activity.
- Despite these changes, mitochondrial integrity and certain energy-related metabolites seemed to remain stable, suggesting that while oxidative stress impacts some parameters, mitochondrial function may not be severely compromised during aging.
Hepatic steatosis is a major risk factor in ischemia-reperfusion (I/R). IGF-binding proteins (IGFBPs) modulate IGF-I action by transporting circulating IGF-I to its sites of action. Epidermal growth factor (EGF) stimulates IGF-I synthesis in vitro.
View Article and Find Full Text PDFThis study investigates how the addition of trimetazidine (TMZ) and aminoimidazole-4-carboxamide ribonucleoside (AICAR) to University of Wisconsin (UW) solution protects steatotic livers. Steatotic and nonsteatotic livers were preserved for 24 hours at 4 degrees C in UW and UW with TMZ and AICAR (separately or in combination) and then perfused ex vivo for 2 hours at 37 degrees C. Adenosine monophosphate-activated protein kinase (AMPK) or nitric oxide (NO) synthesis inhibition in livers preserved in UW with TMZ was also investigated.
View Article and Find Full Text PDFTrimetazidine: is it a promising drug for use in steatotic grafts?
World J Gastroenterol
February 2006
Aim: Chronic organ-donor shortage has led to the acceptance of steatotic livers for transplantation, despite the higher risk of graft dysfunction or nonfunction associated with the ischemic preservation period of these organs. The present study evaluates the effects of trimetazidine (TMZ) on an isolated perfused liver model.
Methods: Steatotic and non-steatotic livers were preserved for 24 h in the University of Wisconsin (UW) solution with or without TMZ.
Background/aims: Hepatic steatosis is a risk factor for transplantation. We examined the role of AMP-activated protein kinase (AMPK) and nitric oxide (NO) in the benefits of preconditioning in steatotic liver transplantation.
Methods: Steatotic liver transplantation with or without preconditioning was induced in Zucker rats.