Publications by authors named "C Wunderlich"
Article Synopsis
- * The authors introduce FrozONE (Frozen Organ Nucleus Enrichment), a new workflow designed to enhance nuclear enrichment from frozen tissues, overcoming the limitations of traditional methods.
- * FrozONE is presented as a faster, simpler, and more scalable alternative, demonstrating effectiveness in profiling nuclear proteomes across different tissues and conditions, including analysis of liver alterations in diet-induced nonalcoholic steatohepatitis.
The world heritage object Nebra Sky Disc is one of the best investigated archaeological objects. The origin of the raw materials it is made of is well known. However, its manufacturing process was not completely clear.
View Article and Find Full Text PDFMost single-photon emission computed tomography (SPECT) scanners employ a gamma camera with a large scintillator crystal and 50-100 large photomultiplier tubes (PMTs). In the past, we proposed that the weight, size and cost of a scanner could be reduced by replacing the PMTs with large-area silicon photomultiplier (SiPM) pixels in which commercial SiPMs are summed to reduce the number of readout channels. We studied the feasibility of that solution with a small homemade camera, but the question on how it could be implemented in a large camera remained open.
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- The study introduces a new method for accessing the cephalic vein (CVP) for implanting cardiac devices, which may lead to fewer complications and easier learning for healthcare providers.
- It analyzed data from 229 patients, with a focus on CVP as the main access route and found a 90% success rate for lead implantation using this method.
- The results show that CVP is as efficient as the traditional subclavian vein puncture (SVP) while having lower complication rates, suggesting it could become the preferred approach for these procedures.
Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in nutrient availability has remained unaddressed. Here, we found that sensory food perception rapidly induced mitochondrial fragmentation in the liver through protein kinase B/AKT (AKT)-dependent phosphorylation of serine 131 of the mitochondrial fission factor (MFFS131). This response was mediated by activation of hypothalamic pro-opiomelanocortin (POMC)-expressing neurons.
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