Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations.

Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antibodies ineffective. Here, we use pseudovirus deep mutational scanning to measure how all single amino-acid mutations to G affect cell entry and neutralization by a panel of antibodies.

Analysis of participant race and sex reporting and disparities in US epilepsy clinical trials.

Objective: Studies have shown that a growing number of people with epilepsy belong to minority groups and experience health disparities. Inclusivity in clinical trial enrollment is essential for advancing health access but has not been well studied among epilepsy trials. The objective of this study was to analyze US epilepsy clinical trials to identify the prevalence and trends associated with race and sex enrollment disparities.

Engineering biology approaches to modulate bacterial biofilms.

Building on a productive two decades of advancements in synthetic biology, engineering biology now promises to enable the implementation and scale-up of novel biological systems tailored to tackle urgent global challenges. Here we explore the latest engineering biology approaches for the control and modification of bacterial biofilms with exciting new functionalities.

Venus cloud catcher as a proof of concept aerosol collection instrument.

We report on the proof-of-concept of a low-mass, low-power method for collecting micron-sized sulfuric acid aerosols in bulk from the atmosphere of Venus. The collection method uses four wired meshes in a sandwich structure with a deposition area of 225 cm. It operates in two modes: passive and electrostatic.