Publications by authors named "C Workman"
Lymphocyte activation gene 3 (LAG3) is a key receptor involved in the propagation of pathological proteins in Parkinson's disease (PD). This study investigates the role of neuronal LAG3 in mediating the binding, uptake, and propagation of α-synuclein (αSyn) preformed fibrils (PFFs). Using neuronal LAG3 conditional knockout mice and human induced pluripotent stem cells-derived dopaminergic (DA) neurons, we demonstrate that LAG3 expression is critical for pathogenic αSyn propagation.
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- Cancer treatment is shifting towards immunotherapy, with immune checkpoint inhibitors (ICIs) showing promising results in improving patient survival rates.
- The FDA has recently approved a combination therapy involving LAG3 and PD1 inhibitors for advanced melanoma patients, paving the way for further research.
- Ongoing clinical trials are exploring new LAG3-targeted treatments, including bispecific antibodies that aim to reactivate exhausted T cells in the fight against cancer.
: Understanding how dual-tasking and Parkinson's disease medication affect gait and balance regularity can provide valuable insights to patients, caregivers, and clinicians regarding frailty and fall risk. However, dual-task gait and balance studies in PD most often only employ linear measures to describe movement regularity. Some have used nonlinear techniques to analyze PD performances, but only in the on-medication state.
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- This study is a retrospective analysis comparing various metrics (mean work RVUs, operative time, and efficiency measured as wRVUs/min) for single- and multilevel cervical spine fusions conducted from 2011 to 2020.
- The researchers examined data for nearly 101,000 patients, focusing on anterior cervical discectomy and fusion (ACDF) versus posterior cervical decompression and fusion (PCDF), finding that anterior fusions were typically quicker but varied in efficiency depending on the number of fusion levels.
- Results highlighted significant differences between the surgical approaches, indicating that while anterior fusions had lower wRVUs in single and multi-level procedures, they were more efficient in the 1- and 2-level categories
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- Women with substance use issues during pregnancy fear losing their children and face stigmas and barriers when seeking help, such as having to repeatedly share their experiences.
- The study assessed a service coordination program for these women and their families over four years at three different sites, focusing on stakeholder interest, feasibility, and program effectiveness.
- A total of 182 women and their families participated, receiving support from patient navigators, and the program proved to be effective and satisfactory, with participants staying for an average of 655 days.