Publications by authors named "C Winstead"

Amidst a critical shortage of registered nurses, nursing schools are aiming to expand enrollment while working with ongoing resource constraints. Service-learning clinical activities can enhance nursing education by improving clinical quality, addressing faculty and clinical site shortages, and meeting increasing enrollment demands. This paper describes a health fair experience that served as a service-learning clinical experience within an undergraduate public health nursing course.

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Here, we synthesized and characterized a novel two-dimensional (2D) conjugated electron donor-acceptor (D-A) copolymer (PBDB-T-Ge), wherein the substituent of triethyl germanium was added to the electron donor unit of the polymer. The Turbo-Grignard reaction was used to implement the group IV element into the polymer, resulting in a yield of 86%. This corresponding polymer, PBDB-T-Ge, exhibited a down-shift in the highest occupied molecular orbital (HOMO) level to -5.

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Rare events are of particular interest in synthetic biology because rare biochemical events may be catastrophic to a biological system by, for example, triggering irreversible events such as off-target drug delivery. To estimate the probability of rare events efficiently, several weighted stochastic simulation methods have been developed. Under optimal parameters and model conditions, these methods can greatly improve simulation efficiency in comparison to traditional stochastic simulation.

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A near ultraviolet transition of MgF has been observed in emission from the reaction between magnesium clusters, most likely Mg, and fluorine atoms. Because there is little evidence for upper-state internal excitation, the spectrum is assigned assuming that the upper state is quenched to its lowest vibrational levels. Two of possibly three ground-state vibrational frequencies, υ = 516 ± 10 cm and υ = 104 ± 10 cm, have been established.

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Article Synopsis
  • IgA nephropathy may be driven by autoimmune processes, where galactose-deficient IgA1 interacts with specific IgG autoantibodies, causing immune complex formation and kidney damage.
  • Experimental studies using immunodeficient mice revealed that only IgG from IgA nephropathy patients, when mixed with Gd-IgA1, led to kidney injuries characterized by abnormal deposits and symptoms like hematuria and proteinuria, while controls did not cause harm.
  • The research offers crucial in vivo evidence supporting the pathogenic role of these IgG autoantibodies, showing they disturb gene expression in kidney tissues similar to that observed in human IgA nephropathy patients.
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