Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors.

Chronic liver injury characterized by unresolved hepatitis leads to fibrosis, potentially progressing to cirrhosis and hepatocellular carcinoma. Effective treatments for halting or reversing liver fibrosis are currently lacking. This study investigates the potential of HDAC6 as a therapeutic target in liver fibrosis.

Bibliometrics of the Dental Implant Literature: Journals, Countries, and Top-Cited Papers.

Background: One potential consequence of the multiplicity of bibliometric studies on dental implants is the emergence of a multifaceted image of the literature on implantology; hence complicating analysis and comprehension by readers.

Aim: In order to reduce or correct this distortion and to help readers in their interpretation, we review and analyze the bibliometrics of the dental implant (BDI) literature.

Method: Using multiple keywords related to dental implants using databases and general internet browsers, we collected and investigated 49 bibliometric studies through the lens of participating journals, contributing countries, and top-cited papers.

Parent Attitudes to Research Without Prior Consent in Two Pediatric Emergency Clinical Trials in Australia: A Qualitative Study of Transcripts From 2017.

Objectives: Research in critically ill children poses challenges in acquiring prospective informed consent. International ethical guidelines generally have provisions to perform research without prior consent (RWPC) in circumstances where consent is not feasible, but there is a paucity of data regarding the community acceptance of this process. The objectives of the current study were to explore the attitudes and experiences of parents of children enrolled into trials to determine understanding and acceptability of RWPC to parents of children involved.

On the distance to the transition state of protein folding in optical tweezers experiments.

The distance to the transition state ( ) is an important parameter for understanding the energy landscape of chemical reactions. In protein folding, represents the distance to the high energy structure between folded and unfolded states. This correlates with the deformation of the protein as it crosses the energy barrier defining its rigidity.

Optimising invitation and advance notification letters to increase bowel cancer screening participation: A qualitative analysis.

Objectives: To explore how letters distributed in population bowel cancer screening programmes could be modified to increase bowel cancer screening uptake, from the perspective of screening invitees.

Methods: Sixty-three people aged 48-74 years discussed their preferences regarding letter design and content during semi-structured interviews aided by various example letters designed to notify of, or invite participants to, the Australian National Bowel Cancer Screening Programme (NBCSP). Deductive thematic analysis, informed by the Integrated Screening Action Model (I-SAM), was used to interpret participant feedback and provide recommendations for improvements to the letters in alignment with the theoretical stages of bowel cancer screening behaviour (engaging, deciding, and completing the screening kit).