Fertility outcomes post immune checkpoint inhibitor exposure.

Harrold et al. evaluate the fertility impact of checkpoint inhibitor blockade (ICB), demonstrating that unlike in utero exposure, post-exposure conception appears to result in uncomplicated pregnancies and healthy progeny. They demonstrate contemporaneous monitoring of temporal female hormonal fluctuations before, on, and post ICB exposure and prior to successful embryo implantation.

First look at neutron emission shape characteristics of ignition hotspots at the National Ignition Facility (invited).

The nuclear imaging system has been capturing neutron images of inertial confinement fusion (ICF) driven implosions for over a decade at the National Ignition Facility. This imaging system has evolved from one to three nearly orthogonal lines-of-sight, allowing for the study of three-dimensional shape characteristics of ignition shots. Limited-view tomography algorithms help visualize the burning hotspot in 3D and assess neutron source geometry using Legendre mode parameters.

Optically multiplexed neutron time-of-flight technique for inertial confinement fusion.

Neutron time-of-flight (nTOF) detectors are crucial in diagnosing the performance of inertial confinement fusion (ICF) experiments, which implode targets of deuterium-tritium fuel to achieve thermonuclear conditions. These detectors utilize the fusion neutron energy spectrum to extract key measurements, including the hotspot ion temperature and fuel areal density. Previous work [Danly et al.

Source shape estimation for neutron imaging systems using convolutional neural networks.

Neutron imaging systems are important diagnostic tools for characterizing the physics of inertial confinement fusion reactions at the National Ignition Facility (NIF). In particular, neutron images give diagnostic information on the size, symmetry, and shape of the fusion hot spot and surrounding cold fuel. Images are formed via collection of neutron flux from the source using a system of aperture arrays and scintillator-based detectors.