An afternoon nap facilitates analogical transfer in creative problem solving.

In analogical problem solving, the solution to a previously experienced problem (source) is used to solve a new but structurally similar problem (target). Yet, analogical transfer is seldom successful, as structural commonalities between source and target problems can be difficult to recognise. Theoretically, memory consolidation processes during REM sleep may help to identify and strengthen connections between weakly related memories, improving the ability to use analogical transfer.

Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity.

Safety and efficacy of cancer-targeting treatments can be improved by conditional activation enabled by the distinct milieu of the tumour microenvironment. Proteases are intricately involved in tumourigenesis and commonly dysregulated with elevated expression and activity. Design of prodrug molecules with protease-dependent activation has the potential to increase tumour-selective targeting while decreasing exposure to healthy tissues, thus improving the safety profile for patients.

Blackouts and hangover experiences among Hispanic and Non-Hispanic White college students.

Blackouts and hangovers may negatively impact college students' health and productivity. However, few studies have considered the impact of cultural differences on students' individual experiences with blackouts and hangovers. To address this issue, the current study explored the potential relationships of shame and resilience with Hispanic ( = 381) and non-Hispanic White (NHW,  = 332) students' self-reported blackouts and hangover experiences.

Mendelian gene identification through mouse embryo viability screening.

Background: The diagnostic rate of Mendelian disorders in sequencing studies continues to increase, along with the pace of novel disease gene discovery. However, variant interpretation in novel genes not currently associated with disease is particularly challenging and strategies combining gene functional evidence with approaches that evaluate the phenotypic similarities between patients and model organisms have proven successful. A full spectrum of intolerance to loss-of-function variation has been previously described, providing evidence that gene essentiality should not be considered as a simple and fixed binary property.

A brief nap during an acute stressor improves negative affect.

Overnight sleep can reduce perceived stress, and improve associated cognitive disruptions and negative affect after an acute stressor. Whether a brief nap can also bestow these benefits in a non-sleep-restricted population is currently unknown. In this study that used a between-subjects design, stress was triggered by administering a modified Trier Social Stress Test to two groups of participants (nap [n = 29], wake [n = 41]).