Publications by authors named "C Welinder"
Article Synopsis
- Pulmonary tuberculosis (TB) can lead to lasting damage in lung tissue, and mycobacterial vesicles (MVs) are being studied for their role in TB-related issues.
- Research showed that stress from TB antibiotics increased MV formation, with vesicles being around 40 nm and containing various lipids and different protein profiles based on the type of antibiotic used.
- While these MVs weren't toxic to human cells, they did provoke specific inflammatory responses, suggesting that they could be significant players in TB pathology.
ADAR3 is a catalytically inactive member of the family of adenosine deaminases acting on RNA (ADARs). Here we have investigated its function in the context of the developing mouse brain. The expression of ADAR3 gradually increases throughout embryogenesis and drops after birth.
View Article and Find Full Text PDFIntroduction: While Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI therapy.
Methods: Evaluating previously reported proteins in two untreated melanoma cohorts, we used a published predictive model (EaSIeR score) to identify potential proteins distinguishing responders and non-responders.
Introduction: Proteomic analysis of injured human peripheral nerves, particularly focusing on events occurring in the proximal and distal nerve ends, remains relatively underexplored. This study aimed to investigate the molecular patterns underlying a digital nerve injury, focusing on differences in protein expression between the proximal and distal nerve ends.
Methods: A total of 26 human injured digital nerve samples (24 men; 2 women; median age 47 [30-66] years), harvested during primary nerve repair within 48 h post-injury from proximal and distal nerve ends, were analyzed using mass spectrometry.