Spin multiplicity effects in doublet singlet emission: the photophysical consequences of a single electron.

Ambient-stable fluorescent radicals have recently emerged as promising luminescent materials; however, tailoring their properties has been difficult due to the limited photophysical understanding of open-shell organic systems. Here we report the experimental and computational analysis of a redox pair of π-conjugated fluorescent molecules that differ by one electron. A π-dication () and π-radical cation () demonstrate different absorption spectra, but similar red emission ( = ∼630 nm), excitation maxima ( = ∼530 nm), fluorescence lifetimes (1-10 ns), and even excited-state (non-emissive) lifetimes when measured by transient absorption spectroscopy.

Open-Shell Effects on Optoelectronic Properties: Antiambipolar Charge Transport and Anti-Kasha Doublet Emission from a -Substituted Bisphenalenyl.

By stabilizing unpaired spin in the ground state, open-shell π-conjugated molecules can achieve optoelectronic properties that are inaccessible to closed-shell compounds. Here, we report the synthesis and characterization of a -substituted, bisphenalenyl π-radical cation [(OTf)] that shows antiambipolar charge transport and fluorescence via anti-Kasha doublet emission. (OTf) produces a red emission (634-659 nm) by radiative decay from β-LUMO to β-SOMO, based on density functional theory and configuration interaction singles calculations, and records one of the highest photostabilities ( = 9.

Pruritus in patients with chronic leg ulcers: A frequent and often neglected problem.

There is a paucity of studies regarding pruritus in patients with chronic leg ulcers. Data were collected using newly developed questionnaires for patients and physicians to evaluate pruritus in individuals with chronic leg ulcers. The results show that a total of 50 patients with chronic leg ulcers were included in this prospective study.

A Concise Synthetic Strategy for Accessing Ambient Stable Bisphenalenyls toward Achieving Electroactive Open-Shell π-Conjugated Materials.

Open-shell, π-conjugated molecules represent exciting next-generation materials due to their unique optoelectronic and magnetic properties and their potential to exploit unpaired spin densities to engineer exceptionally close π-π interactions. However, prior syntheses of ambient stable, open-shell molecules required lengthy routes and displayed intermolecular spin-spin coupling with limited dimensionality. Here we report a general fragment-coupling strategy with phenalenone that enables the rapid construction of both biradicaloid (Ph- s-IDPL, 1) and radical [10(OTf)] bisphenalenyls in ≤7 steps from commercial starting materials.

[Secukinumab-induced subacute-cutaneous lupus erythematosus].

We report about a 52-year-old woman with onset of drug-induced lupus erythematosus (DILE) in sun-exposed areas, under therapy with secukinumab. Topical therapy with a steroid class 3 for 4 weeks showed substantial improvement. The systemic therapy was switched to ustekinumab.