Publications by authors named "C Weenink"
Article Synopsis
- The study examined the effects of low-dose computed tomography (CT) screening on lung cancer mortality in male smokers and found that those who underwent screening had significantly lower mortality rates compared to control.
- Average adherence to screening was high among men at 90.0%, with a low referral rate for suspicious nodules (2.1%) and additional scans.
- Results indicated a 24% reduction in lung cancer deaths at 10 years for the screening group (2.50 deaths per 1000 person-years) compared to the control group (3.30 deaths per 1000 person-years), and similar trends were observed in women, although results were less definitive.
Objectives: Although exponential growth is assumed for lung cancer, this has never been quantified in vivo. Aim of this study was to evaluate and quantify growth patterns of lung cancers detected in the Dutch-Belgian low-dose computed tomography (CT) lung cancer screening trial (NELSON), in order to elucidate the development and progression of early lung cancer.
Materials And Methods: Solid lung nodules found at ≥3 CT examinations before lung cancer diagnosis were included.
Background: In the USA annual lung cancer screening is recommended. However, the optimal screening strategy (eg, screening interval, screening rounds) is unknown. This study provides results of the fourth screening round after a 2.
View Article and Find Full Text PDFPulmonary subsolid nodules (SSNs) have a high likelihood of malignancy, but are often indolent. A conservative treatment approach may therefore be suitable. The aim of the current study was to evaluate whether close follow-up of SSNs with computed tomography may be a safe approach.
View Article and Find Full Text PDFBackground: The main challenge in CT screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer. Management protocols use thresholds for nodule size and growth rate to determine which nodules require additional diagnostic procedures, but these should be based on individuals' probabilities of developing lung cancer. In this prespecified analysis, using data from the NELSON CT screening trial, we aimed to quantify how nodule diameter, volume, and volume doubling time affect the probability of developing lung cancer within 2 years of a CT scan, and to propose and evaluate thresholds for management protocols.
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