Publications by authors named "C Weekes"
Purpose: Preclinical studies have identified molecular correlates of sensitivity to ATR inhibition. This translational study was designed to test the ATR inhibitor berzosertib in patients with advanced solid tumors carrying alterations in ATRX, ataxia-telangiectasia-mutated (ATM), genes conferring replication stress (RS), or SDH.
Patients And Methods: Patients were recruited to four cohorts: T1: ATRX-mutant leiomyosarcoma; T2: ATM-mutant solid tumors; T3: solid tumors with mutations in RS-associated genes; and T4: SDH-deficient gastrointestinal stromal tumors (GIST).
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a fast-growing cancer characterized by significant tumor-related fibrosis, complicating treatment monitoring due to the lack of reliable imaging tools.
- * The study investigates the use of Ga-CBP8, a type I collagen-specific PET imaging probe, to assess changes in tumor fibrosis in response to chemoradiotherapy in PDAC mouse models and patients.
- * Results show that Ga-CBP8 effectively distinguishes between treatment responders and non-responders, demonstrating higher signal in treated versus untreated tissues and suggesting its potential as a monitoring tool in clinical settings.
Background & Aims: Chimeric Antigen Receptor (CAR) T-cell therapy has emerged as a revolutionary treatment for patients with refractory or relapsed B-cell malignancies. However, a significant proportion of patients experience negative outcomes, including severe inflammatory toxicities and relapse. Cachexia and malnutrition are known secondary syndromes in many cancer patients, attributed to the effects of active malignancy, systemic inflammation, and cumulative treatment burden; however, further research is required to accurately characterise these issues in CAR T-cell patients.
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