Publications by authors named "C Warnes"
Article Synopsis
- - Flaviviruses are a group of viruses that cause serious diseases in humans, including dengue and Zika, and rely on a protein called NS1 for replication and disease severity.
- - NS1 is secreted from infected cells and contributes to endothelial dysfunction, which affects blood vessel permeability and may facilitate the spread of the virus in the body.
- - Research demonstrates that NS1 aids in the virus's ability to cross endothelial barriers and boosts the infectivity of specific target cells, indicating its crucial role in virus dissemination and its impact on disease progression.
Article Synopsis
- The study investigates the relationship between yellow fever virus (YFV) nonstructural protein 1 (NS1) and disease severity in yellow fever (YF) patients, highlighting how increased NS1 levels correlate with vascular dysfunction and severe clinical outcomes.
- Researchers analyzed serum samples from patients with severe and non-severe YF cases, finding higher levels of NS1 and syndecan-1 (a vascular leak marker) in severe cases.
- Results indicate that YFV NS1 contributes to endothelial dysfunction by inducing shedding of syndecan-1, suggesting these serum markers could be used for diagnosing and predicting disease severity in YF.
Chikungunya can result in debilitating arthralgia, often presenting as acute, self-limited pain, but occasionally manifesting chronically. Little is known about differences in chikungunya-associated arthralgia comparing children to adults over time. To characterize long-term chikungunya-associated arthralgia, we recruited 770 patients (105 0-4 years old [y/o], 200 5-9 y/o, 307 10-15 y/o, and 158 16+ y/o) with symptomatic chikungunya virus infections in Managua, Nicaragua, during two consecutive chikungunya epidemics (2014-2015).
View Article and Find Full Text PDFBackground: Little is known about outcomes following heart failure (HF) hospitalization among adults with congenital heart disease (CHD) in the United States. We aim to compare the outcomes of HF versus non-HF hospitalizations in adults with CHD.
Methods And Results: Using a national deidentified administrative claims data set, patients with adult congenital heart disease (ACHD) hospitalized with and without HF (ACHDHF+, ACHDHF-) were characterized to determine the predictors of 90-day and 1-year mortality and quantify the risk of mortality, major adverse cardiac and cerebrovascular events, and health resource use.
Yellow fever virus (YFV) infections can cause severe disease manifestations, including hepatic injury, endothelial damage, coagulopathy, hemorrhage, systemic organ failure, and shock, and are associated with high mortality in humans. While nonstructural protein 1 (NS1) of the related dengue virus is implicated in contributing to vascular leak, little is known about the role of YFV NS1 in severe YF and mechanisms of vascular dysfunction in YFV infections. Here, using serum samples from qRT-PCR-confirmed YF patients with severe (n=39) or non-severe (n=18) disease in a well-defined hospital cohort in Brazil, plus samples from healthy uninfected controls (n=11), we investigated factors associated with disease severity.
View Article and Find Full Text PDF