Impaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression.

Adolescent depression is a globally concerned mental health issue, the pathophysiological mechanisms of which remain elusive. Membrane lipids play a crucial role in brain development and function, potentially serving as a crossroad for the abnormalities in neurotransmitters, neuroendocrine, inflammation, oxidative stress, and energy metabolism observed in depressed adolescents. The primary aim of this study was to investigate the erythrocyte membrane lipid profile in adolescent depression.

USP18 Promotes Cholesterol Efflux and Mitigates Atherosclerosis by Deubiquitinating ABCG1.

Deubiquitinating enzymes (DUBs) are integral regulators of protein stability. Among these, Ubiquitin-specific protease 18 (USP18) has emerged as a potential therapeutic target for heart failure. However, its precise role in atherosclerosis remains to be comprehensively understood.

Why is learning from patient safety incidents (still) so hard? A sociocultural perspective on learning from incidents in healthcare organizations.

Purpose: Despite robust quality improvement efforts in healthcare, learning from patient safety incidents remains difficult. Our study explores counter-vailing powers shaping learning processes and possibilities in healthcare organizations, with a focus on social, political and organizational dynamics of learning.

Design/methodology/approach: Deploying concepts of situated curriculum, boundary work and interconnected knowledge practices, we interviewed staff and physicians ( = 15) in a large Academic Health Science Centre in Canada about their experiences of incident investigations and resultant information sharing.

Treated wastewater disturb the distributions of microplastics in their receiving watersheds.

Microplastics (MPs) are ubiquitous in aquatic environments, threatening the security of aquatic organisms. Identifying the emission node and hot spot of MPs holds significant importance in the pollution control of MPs. Wastewater is widely recognized as sink and source of MPs, while the direct evidence is insufficient.

Erosion-Corrosion Behavior of 316L Stainless Steel in Chloropropene.

The objective of this study is to investigate the impact of different pH values and chloropropene flow rates on the erosion-corrosion behavior of 316L stainless steel. The influence of various factors on the surface morphology was analyzed using scanning electron microscopy, X-ray powder diffractometry, and electrochemical impedance spectroscopy techniques. The results revealed that at a pH value of 3.