Publications by authors named "C W Wouters"
SARS-CoV-2 infection poses a major threat to public health, and understanding the mechanism of viral replication and virion release would help identify therapeutic targets and effective drugs for combating the virus. Herein, we identified E3 ubiquitin-protein ligase Itchy homolog (ITCH) as a central regulator of SARS-CoV-2 at multiple steps and processes. ITCH enhances the ubiquitination of viral envelope and membrane proteins and mutual interactions of structural proteins, thereby aiding in virion assembly.
View Article and Find Full Text PDFUnlabelled: Chronic non-bacterial osteomyelitis (CNO) is caused by aseptic inflammation of bones, primarily driven by the innate immune system. CNO may display different clinical presentations (acute vs chronic, uni- vs multifocal) and is accompanied by other inflammatory disorders in up to a third of patients. Once considered a rare disorder, it has become clear that many patients were underdiagnosed.
View Article and Find Full Text PDFMevalonate kinase deficiency (MKD), a rare auto-inflammatory disorder, arises from mutations in the gene, disrupting isoprenoid biosynthesis, and affecting cellular processes. This comprehensive review provides an updated perspective on MKD, including its aetiology, pathogenesis, diagnostic modalities, and therapeutic strategies. Based on recent research and clinical advances, our objective is to bridge the knowledge gaps in the 2015 SHARE guidelines.
View Article and Find Full Text PDFPurpose: To review the existing literature to evaluate the utility of insulin eye drops as a treatment for neurotrophic-related epithelial defects.
Methods: A comprehensive literature search of Medline, Embase, and Web of Science and additional manual searches were conducted using relevant keywords. All articles published from January 2005 to January 2024 were examined.
Article Synopsis
- Hypoglycin A (HGA) and methylenecyclopropylglycine (MCPrG) are harmful compounds from certain plants that cause atypical myopathy (AM) in horses by disrupting energy metabolism.
- The study developed a zebrafish embryo model to test the toxicity of these compounds and found that HGA and its metabolite had lethal effects, while MCPrG did not from concentrations tested.
- Notable increases in specific metabolic compounds were observed post-exposure, and glycine and carnitine were found to be effective in reducing mortality, indicating the potential of the zebrafish model for screening AM treatments.