Delivering Guideline-Concordant Care for Patients With High-Risk HPV and Normal Cytologic Findings.

Importance: As US health care systems shift to human papillomavirus (HPV)-based cervical cancer screening, more patients are receiving positive high-risk non-16/18 genotype HPV results and negative for intraepithelial lesion or malignancy (NILM) cytological findings. Risk-based management guidelines recommend 2 consecutive negative annual results to return to routine screening.

Objective: To quantify patterns of surveillance testing and associated outcomes for patients after an HPV-positive results and NILM cytologic findings.

Impaired Presynaptic Function Contributes Significantly to the Pathology of Glycine Receptor Autoantibodies.

Background And Objectives: Autoantibodies (aAbs) against glycine receptors (GlyRs) are mainly associated with the rare neurologic diseases stiff person syndrome (SPS) and progressive encephalomyelitis with rigidity and myoclonus (PERM). GlyR aAbs are also found in other neurologic diseases such as epilepsy. The aAbs bind to different GlyR α-subunits and, more rarely, also to the GlyR β-subunit.

Drought in a warmer, CO-rich climate restricts grassland water use and soil water mixing.

Soil water sustains terrestrial life, yet its fate is uncertain under a changing climate. We conducted a deuterium labeling experiment to determine whether elevated atmospheric carbon dioxide (CO), warming, and drought impact soil water storage and transport in a temperate grassland. Elevated CO created a wetter rootzone compared with ambient conditions, whereas warming decreased soil moisture.

Uptake of metals, metalloids, and radiocesium varies with habitat use among passerine communities at coal combustion and nuclear fission legacy waste sites.

Releases of coal combustion and nuclear fission wastes create contaminated landscapes that pose long-term management challenges. Efforts to facilitate the natural attenuation of legacy wastes in the environment can provide attractive habitat for passerine birds. Passerines have diverse foraging and nesting behaviors that lead to heterogenous contaminant exposure, yet few studies investigate contaminant uptake in passerines on a community scale.

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch.

Diabetes mellitus type 2 (DMT2) promotes Achilles tendon (AS) degeneration and exercise could modulate features of DMT2. Hence, this study investigated whether tenocytes of non DMT2 and DMT2 rats respond differently to normo- (NG) and hyperglycemic (HG) conditions in the presence of tumor necrosis factor (TNF)α or cyclic stretch. AS tenocytes, isolated from DMT2 (fa/fa) or non DMT2 (lean, fa/+) adult Zucker Diabetic Fatty (ZDF) rats, were treated with 10 ng/mL TNFα either under NG or HG conditions (1 g/L vs.