Publications by authors named "C W Ritz"
Background: People living with cystic fibrosis in Denmark had early, universal access to triple modulator treatment with elexacaftor/tezacaftor/ivacaftor. Close monitoring allowed us to assess the impact of treatment on lung function and progression of lung disease in an unselected nationwide cystic fibrosis population from 6 years of age.
Methods: Data were analysed using linear mixed-effect models to assess changes in levels and annual rates of change (slopes) in percent predicted (pp) forced expiratory volume in 1 s (FEV), forced vital capacity (FVC) and forced expiratory flow at 25-75% of FVC (ppFEF) between the 12 months pre-treatment and treatment periods.
Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study.
Antimicrob Resist Infect Control
November 2024
Article Synopsis
- * A study at Haukeland University Hospital analyzed 523 patients, finding that while a high percentage received antibiotics quickly, only 20.2% adhered to the recommended duration of treatment, with certain factors linked to longer therapy times.
- * The findings indicated that most deviations from guidelines were due to planned post-discharge treatments, highlighting a need for better adherence to antibiotic duration guidelines, despite effective initial empirical therapy choices.
MYC-driven medulloblastoma (MB) is a highly aggressive cancer type with poor prognosis and limited treatment options. Through CRISPR-Cas9 screening of MB cell lines, we identified the Mediator-associated kinase CDK8 as a critical regulator of MYC-driven MB. Loss of CDK8 substantially reduces MYC expression, induces pronounced transcriptional changes, suppresses monosome assembly, and decreases ribosome biogenesis and protein synthesis, consequently inhibiting MB growth.
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- The study investigates the relationship between adiponectin (ADP) levels, glucose metabolism, and body composition in adults with cystic fibrosis-related diabetes (CFRD).
- It was found that while ADP levels were negatively correlated with indicators of insulin resistance and lower body mass metrics, they did not show a correlation with glucose intolerance.
- The findings suggest that malnutrition in cystic fibrosis may contribute to elevated ADP levels, indicating a complex interaction between body composition and glucose metabolism in these patients.
Community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) often result in sudden and persistent reduction in health-related quality of life (HRQoL), which may be alleviated with palliative care. Among individuals with COPD, we aimed to investigate potential associations between HRQoL at admission with CAP and the risk of re-hospitalization and mortality and potential associations between specific HRQoL domains and CAP treatment outcomes. HRQoL was assessed at admission and the participants were grouped into tertiles based on the HRQoL utility index and specific domains.
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