Publications by authors named "C W Radtke"
Spider silk (SPSI) is a promising candidate for use as a filler material in nerve guidance conduits (NGCs), facilitating peripheral nerve regeneration by providing a scaffold for Schwann cells (SCs) and axonal growth. However, the specific properties of SPSI that contribute to its regenerative success remain unclear. In this study, the egg sac silk of is investigated, which contains two distinct fiber types: tubuliform (TU) and major ampullate (MA) silk.
View Article and Find Full Text PDFBreast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare lymphoma primarily linked to textured breast implants. Symptoms are often non-specific (e.g.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the diversity of cancer-associated fibroblasts (CAFs) in various skin cancers, including basal cell carcinoma, squamous cell carcinoma, and melanoma, using advanced analysis techniques.
- Researchers identify three CAF subtypes: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs), noting that their patterns change with tumor severity.
- The study suggests that targeting specific CAF subtypes could improve the effectiveness of immunotherapy in treating skin cancers, as these cells play distinct roles in tumor progression and immune responses.
Peripheral nerve regeneration depends on close interaction between neurons and Schwann cells (SCs). After nerve injury, SCs produce growth factors and cytokines that are crucial for axon re-growth. Previous studies revealed the supernatant of SCs exposed to nuclear magnetic resonance therapy (NMRT) treatment to increase survival and neurite formation of rat dorsal root ganglion (DRG) neurons in vitro.
View Article and Find Full Text PDFArticle Synopsis
- Researchers have successfully applied spider silk fibers in nerve repair for the first time in humans, following previous successful sheep trials.
- Four patients with nerve defects greater than 20 cm were treated using spider silk conduits within their veins, showing promising results over a follow-up period of 2 to 10 years.
- All patients experienced primary healing without adverse effects, and many regained significant sensory and motor function, indicating spider silk conduits could be a viable option for complex nerve repairs.