Publications by authors named "C W Lapp"
Introduction: Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience cognitive problems with attention, information processing speed, working memory, learning efficiency, and executive function. Commonly, patients report worsening of cognitive symptoms over time after physical and/or cognitive challenges. To determine, monitor, and manage longitudinal decrements in cognitive function after such exposures, it is important to be able to screen for cognitive dysfunction and changes over time in clinic and also remotely at home.
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- * The study analyzed data from 923 participants, revealing that chronic migraines (48.1%), fibromyalgia (45.0%), and chronic low back pain (33.1%) were the most common COPCs among those with ME/CFS.
- * The presence of COPCs significantly worsens health outcomes for ME/CFS patients, particularly affecting pain-related symptoms, with fibromyalgia showing the highest prevalence ratio and effect size.*
Article Synopsis
- The MCAM study aimed to see if different clinicians recognized myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as the same clinical condition by analyzing data from 465 patients across seven specialized clinics in the U.S.
- Research found minimal significant differences in ME/CFS symptoms and functionalities among patients from various clinics, indicating a possible inherent illness heterogeneity.
- The study suggests that representing data visually (like scatter plots) could better illustrate this variation, and emphasizes the need for more detailed subgroup analyses in future research to enhance understanding and reproducibility of ME/CFS findings.
Article Synopsis
- Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness marked by severe fatigue, reduced functionality, and other symptoms, with variations in natural killer (NK) cell counts being explored as a potential biomarker.
- In a study involving over 270 participants, including those with ME/CFS and healthy controls, researchers measured NK cell cytotoxicity but found no significant differences between groups, indicating that NK cell cytotoxicity might not serve as a reliable biomarker for this condition.
- The study concludes that the assay used for measuring NK cytotoxicity is not ready for clinical application and emphasizes the need for further research into immune factors related to ME/CFS.
Background & Aims: Enteroendocrine cells (EECs) and their hormones are essential regulators of whole-body energy homeostasis. EECs sense luminal nutrients and microbial metabolites and subsequently secrete various hormones acting locally or at a distance. Impaired development of EECs during embryogenesis is life-threatening in newborn mice and humans due to compromised nutrient absorption.
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