Publications by authors named "C W Keefe"
Study reproducibility is essential to corroborate, build on, and learn from the results of scientific research but is notoriously challenging in bioinformatics, which often involves large data sets and complex analytic workflows involving many different tools. Additionally, many biologists are not trained in how to effectively record their bioinformatics analysis steps to ensure reproducibility, so critical information is often missing. Software tools used in bioinformatics can automate provenance tracking of the results they generate, removing most barriers to bioinformatics reproducibility.
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- The study investigates the gut microbiota-brain axis in female 3xTg-AD mice, a model for Alzheimer's disease, by analyzing fecal samples and gene expression in the colon and hippocampus over a 52-week period.
- Researchers found distinct gut microbiota differences between 3xTg-AD mice and wild-type controls early in life, with specific immune markers elevated in both the colon and hippocampus indicating neuroinflammation.
- The study highlights that changes in gut bacteria composition can predict the development of Alzheimer's disease pathologies, marking it as the first comprehensive analysis over an extended time frame.
Article Synopsis
- In October 2020, a team hosted their first online workshop teaching how to use a microbiome research tool called QIIME 2, with 75 participants from 25 countries.
- The workshop lasted 5 days and used a special online setup that allowed everyone to work together, and many instructors helped out.
- After receiving feedback, they organized a second workshop in January 2021, made improvements based on suggestions, and planned to share what they learned for future events.
A sellar spine is a midline bony spur arising from the ventral aspect of the dorsum sellae. Representing a remnant of the anterior notochord, it is often an incidental finding and thought to be of no clinical significance. However, it has recently been suggested that a potential association may exist between sellar spine and pediatric pituitary endocrinopathies, possibly caused by deformation of the developing pituitary gland by the sellar spine.
View Article and Find Full Text PDFUnlabelled: Osteoporosis is a major concern in patients with Duchenne muscular dystrophy. In this novel study of teriparatide treatment in 6 patients with severe osteoporosis, bone health (fractures, vertebral morphometry, and DXA) remained stable, with no adverse events. These findings will help inform future osteoporosis research in this challenging population.
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