Pediatric Constraint-Induced Movement Therapy: Current Practices and Implementation Barriers.

Hemiplegic Cerebral Palsy (CP) is the most common pediatric motor disability, characterized by unilateral motor weakness. Pediatric Constraint-Induced Movement Therapy (pCIMT) improves affected extremity function but faces variable clinical integration. This study assessed U.

Partisan Prejudice: The Role of Beliefs About the Unchanging Nature of Ideology and Partisans.

Although there is a tendency to think all forms of essentialism-the belief that characteristics are inherent and unchangeable-are similar, some theories suggest different foundations and outcomes. We investigated if belief systems about the stability of political ideology (trait essentialism) and the fundamental nature of partisans (social essentialism) predict prejudice in opposite ways and if they do so via differential relations with blame. Across six studies ( = 2,231), we found that the more people believe the trait of political ideology is fixed (trait essentialism), the more they think that Republicans and Democrats are inherently different (social essentialism).

Multi-platform biomarkers of response to an immune checkpoint inhibitor in the neoadjuvant I-SPY 2 trial for early-stage breast cancer.

Only a subset of patients with breast cancer responds to immune checkpoint blockade (ICB). To better understand the underlying mechanisms, we analyze pretreatment biopsies from patients in the I-SPY 2 trial who receive neoadjuvant ICB using multiple platforms to profile the tumor microenvironment. A variety of immune cell populations and markers of immune/cytokine signaling associate with pathologic complete response (pCR).

"I was very scared when I found out my son had sickle cell": Caregiver knowledge and attitudes toward early intervention for young children with sickle cell disease: Implications for policy and practice from a multi-site study.

Objective: This study characterized caregivers' beliefs related to early intervention services for children with sickle cell disease (SCD) to gain an indepth understanding of caregivers' experiences and desires for early intervention services.

Methods: Both qualitative and quantitative data were collected from caregivers of children aged 0-4 years with SCD across two sites in the United States. Caregivers completed the Knowledge of Infant Development Inventory, a custom survey about their experiences with early intervention, and a qualitative interview.