Publications by authors named "C W Hendrix"
Background: Tibial shaft fractures are common, causing substantial morbidity. Intramedullary nailing offers advantages but often leads to anterior knee pain and functional issues.
Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic review on outcomes for different surgical approaches-suprapatellar (SP), infrapatellar (IP), medial parapatellar (MPP), and lateral parapatellar (LPP).
This review summarizes recent findings on stress-related programming of brain development , with an emphasis on situating findings within the mothers' broader psychosocial experiences. Meta-analyses of observational studies on prenatal stress exposure indicate the direction and size of effects on child neurodevelopment are heterogeneous across studies. Inspired by lifespan and topological frameworks of adversity, we conceptualize individual variation in mothers' lived experience during and prior to pregnancy as a key determinant of these heterogeneous effects across populations.
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- Introduction of long-acting injectable cabotegravir (CAB-LA) for HIV prevention showed effectiveness, and this study examines its safety and pharmacokinetics in pregnant women participating in the HPTN 084 trial during a blinded period.
- In the study, pregnant participants were divided into two groups receiving either CAB-LA or TDF/FTC, with careful monitoring of pregnancy outcomes and maternal adverse events, finding that there was no significant difference in adverse event rates or poor pregnancy outcomes between the two groups.
- The analysis revealed a total of 57 confirmed pregnancies over 3845 person-years, with 81% resulting in live births, and the study concluded that CAB-LA did not result in significantly different safety or outcomes
Longitudinal changes in tenofovir and tenofovir-diphosphate concentrations among pregnant women using oral PrEP for HIV prevention: Findings from Durban, South Africa.
J Acquir Immune Defic Syndr
December 2024
Background: Pregnant women are vulnerable to HIV acquisition. Oral HIV pre-exposure prophylaxis (PrEP) is safe and effective for use during pregnancy. We describe PrEP adherence among pregnant women using multiple measures.
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