Publications by authors named "C W Henderson"
Article Synopsis
- The study investigates CP symmetry violation in the decay of D^{+} particles into K^{-}K^{+}π^{+} using data from proton-proton collisions at a high energy of 13 TeV.
- A unique model-independent method was employed to analyze the phase-space distributions of D^{+} and D^{-} particles, correcting for any instrumental biases using D_{s}^{+} decays.
- The findings indicate no significant evidence of CP violation, with a p value of 8.1%, and measure specific CP asymmetry observables, marking this study as the most sensitive search of its kind in multibody decays.
Spinal muscular atrophy (SMA) is caused by low levels of the survival motor neuron (SMN) protein. Even though SMN is ubiquitously expressed, the disease selectively affects motor neurons, leading to progressive muscle weakness. Even among motor neurons, certain motor units appear more clinically resistant to SMA.
View Article and Find Full Text PDFBoys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on CMR.
Circ Cardiovasc Imaging
December 2024
Article Synopsis
- Cardiomyopathy is a major cause of death in boys with Duchenne muscular dystrophy (DMD), and this study investigates cardiac function using cardiac magnetic resonance (CMR) imaging to compare DMD patients with healthy controls.
- The study involved 179 DMD patients and 96 healthy controls, focusing on measuring left ventricular (LV) function, with findings demonstrating significant differences in ventricular volumes and ejection rates, indicating compromised cardiac function in DMD patients.
- Results suggest that certain CMR filling and ejection indices correlate with increased mortality in DMD patients, highlighting the potential for these measures to serve as important prognostic tools.
Article Synopsis
- This study explores the feasibility of using Compassion-focused Therapy (CFT) for individuals with dementia who experience anxiety and depression, addressing a gap in evidence-based psychological treatments for this group.
- A total of 50 participants will be randomly assigned to either receive CFT along with usual treatment or just the usual treatment, with evaluations conducted at multiple time points to assess various psychological and relational outcomes.
- The study received ethical approval and aims to share findings through open-access publications, conferences, and feedback to involved parties.
Spinal motor neuron (MN) dysfunction is the cause of a number of clinically significant movement disorders. Despite the recent approval of gene therapeutics targeting these MN-related disorders, there are no viral delivery mechanisms that achieve MN-restricted transgene expression. In this study, chromatin accessibility profiling of genetically defined mouse MNs was used to identify candidate cis-regulatory elements (CREs) capable of driving MN-selective gene expression.
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