Publications by authors named "C W Hanemann"
Article Synopsis
- * This study identifies the overexpression of TAM receptors (TYRO3, AXL, MERTK) and the ligand GAS6 in tumor cells from patients, revealing new interactions between these receptors in meningioma and schwannoma tissues.
- * Researchers found that inhibiting MERTK with UNC2025 and AXL with BGB324 reduced cell growth and survival in vitro, with UNC2025 proving more effective and also depleting tumor-associated macrophages in both tumor types.
Background: External radiation therapy (RT) is often a primary treatment for inoperable meningiomas in the absence of established chemotherapy. Histone deacetylase 6 (HDAC6) overexpression, commonly found in cancer, is acknowledged as a driver of cellular growth, and inhibiting HDACs holds promise in improving radiotherapeutic efficacy. Downregulation of HDAC6 facilitates the degradation of β-catenin.
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- - Meningiomas are the most common primary brain tumors in adults, with an increasing incidence linked to aging and better neuroimaging, and while many are benign, some are aggressive and treatment-resistant, leading to serious health impacts.
- - Recent advancements in understanding meningioma biology have introduced molecular biomarkers for diagnosis and prognosis, but a standardized molecular classification for these tumors is still lacking.
- - A comprehensive consensus review by the International Consortium on Meningiomas aims to guide clinicians and researchers by covering proposed classifications, novel treatment strategies, ongoing studies, and unique management approaches for different patient populations.
Adult brain tumour research in 2024: Status, challenges and recommendations.
Neuropathol Appl Neurobiol
April 2024
Article Synopsis
- In 2015, patient and charity activism led to the formation of a UK government group focused on brain tumor research.
- By 2018, this resulted in a commitment of £20m from the government and £25m from Cancer Research UK for neuro-oncology over five years.
- The review covers changes in the UK's brain tumor research landscape, identifies seven key research priorities, three overarching themes, and discusses the current status and challenges in this field.