Hybrid Biological-Chemical Strategy for Converting Polyethylene into a Recyclable Plastic Monomer Using Engineered Corynebacterium glutamicum.

Converting polyethylene (PE) into valuable materials, particularly ones that are better for the environment than the incumbent plastics, not only helps mitigate environmental issues caused by plastic waste but also alleviates the long-standing problem of microbial fermentation competing with food supplies. However, the inherent robustness of PE due to its strong carbon-carbon bonds and high molecular weight necessitates harsh decomposition conditions, resulting in diverse decomposition outcomes that present significant challenges for downstream applications, especially for bioconversion. In this study, we demonstrate a hybrid biological-chemical conversion process for PE, converting its decomposition products, namely short-chain diacids, into a monomer, β-keto-δ-lactone (BKDL), for highly recyclable polydiketoenimine plastics using engineered Corynebacterium glutamicum.

A novel 5-differentially expressed gene (DEG) signature predicting the prognosis in patients with metastatic liver malignancies and the prognostic and therapeutic potential of SPP1.

Background: This study aimed to identify differentially expressed genes (DEGs) that are associated with hepatocarcinogenesis and metastasis in hepatocellular carcinoma (HCC) and to explore their value in predicting overall survival (OS). The methods used included bioinformatics analysis of gene expression datasets and in vitro experiments using HCC cell lines.

Methods: Gene expression profiles from metastatic and non-metastatic liver cancer specimens were analyzed using the limma R package.

Design of a Full-Range Capacitive Sensor Extensometer Using a High-Precision Ultrasonic Motor.

Extensometers are critical instruments for accurately measuring small displacements in terrain deformation monitoring. Conventional extensometers often employ eddy current displacement sensors or differential transformer sensors, which are constrained by structural limitations that hinder their ability to meet high-precision requirements. The capacitive micro-displacement sensor has a high precision of up to 0.

A multicenter, randomized, double-blind trial comparing LY01011, a biosimilar, with denosumab (Xgeva®) in patients with bone metastasis from solid tumors.

Introduction: Denosumab (Xgeva®) is a standard treatment for the prevention of skeletal-related events (SREs) in patients with bone metastases (BM). This trial was designed to assess the equivalence of LY01011 to denosumab in terms of efficacy and safety.

Materials And Methods: Eligible patients with BM from solid tumors were randomized at a 1:1 ratio to receive 120 mg of LY01011 or 120 mg of denosumab subcutaneously every four weeks during a 12-week double-blind treatment period, and then all enrolled patients continued to receive LY01011 until week 53.

"Rat race" or "lying flat"? The influence of performance pressure on employees' work behavior.

Introduction: Performance pressure refers to employees' subjective perception of the necessity to achieve expected goals, accompanied by a sense of urgency and tension. This study explores how employees cope with performance pressure, focusing on two contrasting strategies: the "rat race" (proactive work behavior) or "lying flat" (work withdrawal). Grounded in the transactional theory of stress and affective event theory, this research aims to uncover the mechanisms through which performance pressure influences work behavior.