Publications by authors named "C W Cowan"
Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as (neuronal PAS domain protein 4). Here we show that a conserved long noncoding enhancer RNA (lnc-eRNA), transcribed from an activity-sensitive enhancer, produces DNA:RNA hybrid R-loop structures that support three-dimensional chromatin looping between enhancer and proximal promoter and rapid gene induction.
View Article and Find Full Text PDFDiet interventions for depression: Review and recommendations for practice.
Aust N Z J Psychiatry
December 2024
Article Synopsis
- This paper discusses how diet can help prevent and treat depression and suggests practice recommendations for mental health professionals.
- The study reviews how healthy dietary patterns, like the Mediterranean and DASH diets, are linked to improved mood and reduced depression symptoms, while also addressing challenges in researching diet's effects.
- It concludes that mental health clinicians should incorporate dietary counseling in their practice and refer patients to dietitians when needed.
Article Synopsis
- Interventionists can enhance coparenting dialogues between fathers and mothers, leading to positive involvement and better child development outcomes.
- The new strategy and rating system developed from relationship enhancement groups helps assess the quality of these coparenting discussions among parents.
- Results show that while coparenting topics are infrequently discussed, when raised, parents are motivated and engaged, and supportive co-leader responses help facilitate deeper conversations.
Here, we investigate the contribution of long-term hematopoietic stem cells (HSCs) to trained immunity (TI) in the setting of chronic autoimmune disease. Using a mouse model of systemic lupus erythematosus (SLE), we show that bone marrow-derived macrophages (BMDMs) from autoimmune mice exhibit hallmark features of TI, including increased Mycobacterium avium killing and inflammatory cytokine production, which are mechanistically linked to increased glycolytic metabolism. We show that HSCs from autoimmune mice constitute a transplantable, long-term reservoir for macrophages that exhibit the functional properties of TI.
View Article and Find Full Text PDFImmunogenicity limits the persistence of off-the-shelf, allogeneic cell therapies and transplants. While ablation of human leukocyte antigen (HLA) removes most T cell and humoral alloreactivity, no solution has enabled universal protection against the resulting natural killer (NK) cell response. Here, we engineered Trans Antigen Signaling Receptors (TASR) as a new class of NK inhibitory ligands and discovered CD300a, a previously inaccessible receptor, as a functional target.
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