Publications by authors named "C W Chukwu"

Background And Objectives: The optimal iron hypothesis (OIH) posits that risk for infection is lowest at a mild level of iron deficiency. The extent to which this protection results from arms race dynamics in the evolution of iron acquisition and sequestration mechanisms is unclear. We evaluated the OIH with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an emerging infectious agent.

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Lysosomal storage diseases (LSDs) encompass a group of rare inherited metabolic disorders characterized by the accumulation of undegraded substrates within lysosomes, leading to multisystemic manifestations, including profound neurological involvement. This article provides a concise overview of the neurological manifestations of LSDs, with a focus on central nervous system (CNS) involvement and treatment strategies. While the paper intricacies of each LSD subtype and its associated CNS manifestations, it aims to provide a summary of the essential findings and implications.

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Heavy metal environmental pollution is rapidly increasing due to the increase in industrialization and urbanization. Industrial processes, such as paint production, mining, and raw materials producing industries release effluents rich in heavy metals, like Pb, Cd, Cu, and Cr. These heavy metals are dangerous because they persist in nature, are non-biodegradable and they have high tendency to accumulate in the environment and in living organisms who are exposed to them.

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Tuberculosis (TB) remains a significant global health concern, necessitating effective control strategies. This article presents a mathematical model to evaluate the comparative effectiveness of medical mask usage and case detection in TB control. The model is constructed as a system of ordinary differential equations and incorporates crucial aspects of TB dynamics, including slow-fast progression, medical mask use, case detection, treatment interventions and differentiation between symptomatic and asymptomatic cases.

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Article Synopsis
  • Nigeria reported its first mpox cases in nearly 40 years five years before the 2022-2023 outbreak, with ongoing human-to-human transmission driving the epidemic.
  • Researchers analyzed 112 mpox virus genomes from Nigeria (2021-2023) and traced the lineage back to its emergence around July 2014 from southern Nigeria, specifically Rivers State.
  • The study also found that human-to-human transmission significantly increased the virus's evolutionary rate and emphasized the importance of better pathogen surveillance and response strategies.
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