Oral squamous-cell carcinoma (OSCC) poses significant treatment challenges due to its high recurrence rates and the limitations of current therapies. Titanium dioxide (TiO) nanoparticles are promising radiosensitizers, while bacterial outer membrane vesicles (OMVs) are known for their immunomodulatory properties. This study investigates the potential of OMV-encapsulated TiO nanoparticles (TiO@OMV) to combine these effects for improved OSCC treatment.
View Article and Find Full Text PDFThe EZ DEVICE is an integrated fluorescence microflow cytometer designed for automated cell phenotyping and enumeration using artificial intelligence (AI). The platform consists of a laser diode, optical filter, objective lens, CMOS image sensor, and microfluidic chip, enabling automated sample pretreatment, labeling, and detection within a single compact unit. AI algorithms segment and identify objects in images captured by the CMOS sensor at 532 and 586 nm emission wavelengths.
View Article and Find Full Text PDFScintillation screens are widely used to diagnose high-charge density, low-average current electron beams from laser wakefield accelerators (LWFAs). However, the absolute response between emitted photons and electron charge has only been calibrated at a limited number of facilities, and there have been discrepancies between these calibrations. In this report, we comprehensively revised the absolute charge calibration of two high relative brightness scintillating screens of LANEX Regular (Carestream) and PI200 (Mitsubishi) by employing the high-brightness photoinjector at the National Synchrotron Radiation Research Center (NSRRC), which provides electron beams with variable charges (50-350 pC per pulse) and energies (26.
View Article and Find Full Text PDFBackground: Immune checkpoint inhibitors (ICIs) are associated with an increased risk of major adverse cardiovascular events (MACE). Glucagon-like peptide-1 agonists (GLP1a), initially developed for type 2 diabetes mellitus (T2DM), have shown promising results in reducing cardiovascular events. We aimed to investigate the effect of GLP1a on cardiovascular events in patients receiving ICIs.
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