Publications by authors named "C W Caldwell"
Article Synopsis
- This study analyzes prognostic factors affecting long-term outcomes and changes in contusion volume in patients with traumatic brain injuries (TBI) due to hemorrhagic cerebral contusions.
- Key findings indicate that older age, larger initial contusion volumes, and lower Glasgow Coma Scale (GCS) scores are linked to worse functional outcomes post-injury.
- The research suggests that the GCS verbal score could predict both initial contusion volume and potential expansion, highlighting its importance in managing and predicting patient outcomes in neurosurgery.
Background: As Alzheimer disease (AD) and AD-related dementias (ADRD) progress, individuals increasingly require assistance from unpaid, informal caregivers to support them in activities of daily living. These caregivers may experience high levels of financial, mental, and physical strain associated with providing care. CareVirtue is a web-based tool created to connect and support multiple individuals across a care network to coordinate care activities and share important information, thereby reducing care burden.
View Article and Find Full Text PDFLong-term health and developmental impact after opioid and other substance exposures is unclear. There is an urgent need for well-designed, prospective, long-term observational studies. The HEALthy Brain and Child Development Study aims to address this need.
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- The study of chromosome segregation has progressed over time, primarily benefiting from advancements in microscopy, with the mitotic spindle being the main source of force generation.
- The kinetochore serves as a crucial interface between microtubules and centromeric chromatin, involving proteins like cohesin and condensin to ensure accurate chromosome separation.
- Current research estimates the forces needed for chromosome separation range from tens to hundreds of piconewtons, but measuring these forces accurately is challenged by existing techniques, though new methods could improve future studies.
Sepsis remains a significant cause of morbidity and mortality worldwide. While many more patients are surviving the acute event, a substantial number enter a state of persistent inflammation and immunosuppression, rendering them more vulnerable to infections. Modulating the host immune response has been a focus of sepsis research for the past fifty years, yet novel therapies have been few and far between.
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